Development of a nine-lncRNA signature as a novel prognostic marker of estrogen receptor-negative breast cancer.

Development of a nine-lncRNA signature as a novel prognostic marker of estrogen receptor-negative breast cancer. Oncol Lett. 2020 Apr;19(4):2979-2988 Authors: Wang Z, Wang J, Liu L, He Q, Wei M Abstract Long non-coding RNAs (lncRNAs) have been demonstrated to be aberrantly expressed in several types of tumor, and dysregulated lncRNAs are suggested to play a prognostic role in breast cancer (BC). Estrogen receptor (ER) status is a prognostic factor in patients with ER-negative BC, which is associated with poor prognosis. Thus, the present study developed a prognostic lncRNA signature specifically for ER-negative BC, in order to predict the risk of post-surgery relapse and improve patient prognosis. A gene expression profile containing 1,631 lncRNAs was obtained by investigating and integrating publicly available cohorts of BC. Subsequently, a nine-lncRNA signature was developed and validated in two independent cohorts via the Cox regression model. Using the nine-lncRNA signature, patients in the discovery cohort were divided into high- and low-risk groups, with significantly different disease-free survival [DFS; hazard ratio (HR)=2.718, 95% confidence interval (CI)=2.115-3.494, P
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

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