Creatinine/(cystatin C × body weight) ratio is associated with skeletal muscle mass index.

Creatinine/(cystatin C × body weight) ratio is associated with skeletal muscle mass index.
Endocr J. 2020 Mar 26;:
Authors: Nishida K, Hashimoto Y, Kaji A, Okamura T, Sakai R, Kitagawa N, Osaka T, Hamaguchi M, Fukui M
Abstract
We have previously reported that the creatinine (Cre) to cystatin C (CysC) ratio is associated with height-adjusted skeletal muscle mass index (SMI). However, weight-adjusted SMI is reported to be a more useful marker of insulin sensitivity than height-adjusted SMI. Thus, we hypothesized that the creatinine to (cystatin C × body weight [BW]) relationship (Cre/[CysC × BW]) might be associated with weight-adjusted SMI. In this cross-sectional study of 169 males and 132 females, a body composition analyzer was used and the weight-adjusted SMI was calculated as (absolute muscle mass [kg]/BW [kg]) × 100. The cut-off of low muscle mass was defined as weight-adjusted SMI <37.0% for males and <28.0% for females. The Cre/(CysC × BW) was correlated with weight-adjusted SMI in both males (r = 0.484, p < 0.001) and females (r = 0.538, p < 0.001). In addition, Cre/(CysC × BW) was associated with weight-adjusted SMI in both males (standardized β = 0.493, p < 0.001) and females (standardized β = 0.570, p < 0.001) after adjusting for covariates. According to the receiver operator characteristic (ROC) curve analysis, the optimal cut-off point of Cre/(CysC × BW) for low muscle mass was 0.0145 (area und...

Source: Endocrine Journal - March 29, 2020 Category: Endocrinology Tags: Endocr J Source Type: research