Nano-curcumin versus curcumin in amelioration of deltamethrin-induced hippocampal damage

In conclusion, oxidative stress is the common mechanism responsible for DLM-induced hippocampal neurotoxicity. It exerts apoptosis of hippocampal neurons through increasing Nrf2, HS-GCS, LS-GCS and decreasing AChE. In addition, it activates astr ocytes through increasing expression of GFAP. The protective role of CMN and CMMN is related to their potent antioxidant effect. Much improvement has been detected with NCMN as compared to CMN.
Source: Histochemistry and Cell Biology - Category: Biomedical Science Source Type: research