Correlation between IDH , ATRX , and TERT promoter mutations in glioma

This study analyzedIDH,ATRX, andTERT promoter mutations, and the correlation between them. Immortalized cells overcome the telomere-related crisis by activating telomerase or ALT. In glioma, telomerase is mainly activated byTERT promoter mutation, while ALT is usually associated withATRX mutation. Although the mechanism of howATRX mutation induces ALT remains unclear, ATRX loss alone is believed to be insufficient to induce ALT. Treatments targeting telomere maintenance are promising.
Source: Brain Tumor Pathology - Category: Neurology Source Type: research