Retinal axonal degeneration in Niemann –Pick type C disease

ConclusionsUsing OCT, we showed retinal degeneration in NPC1-P and significant correlation between retinal neuroaxonal degeneration with clinical measurements. We observed a non-significant trend of retinal degeneration in NPC1-MC correlating with subclinical motor abnormalities. Based on these preliminary data, OCT may be an important marker of neurodegeneration in NPC1-disease after onset of clinical symptoms.

http://link.springer.com/10.1007/s00415-020-09796-2

Source: Journal of Neurology - March 27, 2020 Category: Neurology Source Type: research