Durable Survival Outcomes in Primary and Secondary Central Nervous System Lymphoma After High-dose Chemotherapy and Autologous Stem Cell Transplantation Using a Thiotepa, Busulfan, and Cyclophosphamide Conditioning Regimen

We retrospectively analyzed the data from 48 patients with central nervous system lymphoma who had received high-dose chemotherapy and autologous stem cell transplantation using TBC (thiotepa, busulfan, cyclophosphamide) conditioning. The 2-year progression-free and overall survival rate was 80.5% and 80.1%, respectively. Toxicities included nausea/vomiting, diarrhea, mucositis, and febrile neutropenia. Treatment-related mortality was 8.3% in the first 100 days after transplantation. These data support the use of consolidative autologous stem cell transplantation for patients with primary or secondary central nervous system lymphoma.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research