Volixibat in adults with non-alcoholic steatohepatitis: 24-week interim analysis from a randomized, phase II study

This study investigated whether volixibat could reduce the amount of fat in the liver and reduce liver injury in adults with an advanced form of non-alcoholic fatty liver disease. Volixibat did not reduce the amount of fat in the liver, nor did it have any other beneficial effect on liver injury. Participants in the study generally tolerated the side effects of volixibat and, as in previous studies, the main side effect was diarrhoea. These results show that volixibat is not an effective treatment for people with fatty liver disease.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research

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Conclusions: In the context of this framework, cortisol may serve as a biomarker for the development of AUD, as well as a biomarker of risk or relapse. This review ends with both theoretical and clinical implications, as well as directions for future research. PMID: 32493131 [PubMed - as supplied by publisher]
Source: Journal of Dual Diagnosis - Category: Addiction Tags: J Dual Diagn Source Type: research
The objective of this study was to provide an overview of whether adherence to brain trauma foundation (BTF) guidelines improved outcomes following TBI utilizing intracranial pressure (ICP) monitoring. Methods: This cohort study between 2000 and 2013 involved 1848 patients who sustained severe blunt TBI. Outcomes were correlated with whether or not ICP monitoring was utilized based on BTF guidelines. Results: The BTF guideline adherence rate for utilizing ICP monitoring in patients with TBI was 30% in 1848 patients. Adherence rates positively correlated with younger age, high injury severity scores, lower Glasgow C...
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Publication date: Available online 4 June 2020Source: Food Research InternationalAuthor(s): Alba Tamargo, Diana Martin, Joaquín Navarro del Hierro, M. Victoria Moreno-Arribas, Loreto A. Muñoz
Source: Food Research International - Category: Food Science Source Type: research
CONCLUSIONS: Adapting the HTW definition might improve specificity to assess cardiovascular risk in the population with CKD. It identifies an additional CVR in a population in which other screening methods have not proven to be useful, and it is easily clinically accessible. Its interaction with phosphorus levels suggests an association between HTW and bone-mineral metabolism regulation. PMID: 32493675 [PubMed - as supplied by publisher]
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
AbstractThe current study examined whether husband ’s controlling and domineering attitudes moderated the association between husband’s alcohol consumption and women’s physical violence experience. Using data from the Nigeria Demographic and Health Survey (DHS), a total of 20,101 nationally representative married women in Nigeria reported on h usband-perpetrated physical violence, husband’s alcohol consumption, and husband’s controlling and domineering attitudes. Weighted data were analyzed using zero-inflated negative binomial (ZINB) regression models. The models revealed that women whose hus...
Source: Journal of Family Violence - Category: Psychiatry & Psychology Source Type: research
Dalton Trans., 2020, Advance Article DOI: 10.1039/C9DT04927D, PaperMei-Ling Cheng, Meng-Na Qin, Lin Sun, Lu Liu, Qi Liu, Xiao-Yan Tang A Cu(II)-pyrazoledicarboxylate MOF displayed high activity and selectivity in the base-free oxidation of benzyl alcohol to benzaldehyde combined with H2O2. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
RESUMO: Objetivos: Identificar a preval ência da doença renal crônica (DRC) autorreferida no Brasil e caracterizar os fatores associados a essa enfermidade. Métodos: Trata-se de um inquérito epidemiológico de base domiciliar, a Pesquisa Nacional de Saúde (PNS) realizada em 2013. O desfecho analisado foi a prevalência de DRC. Os grupos de variáveis explicativas foram: características sociodemográficas, estilos de vida, doenças crônicas autorreferidas, antropometria e avaliação de saúde. Foram estimadas as prevalê...
Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
CONCLUSION: The matrix effect caused by exogenous and endogenous interferences in the blood could be a hidden factor increasing the prevalence of vitamin D deficiency by causing falsely low 25OHD3 values. Suspicious results should be remeasured by a dilution study. PMID: 32496995 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
CONCLUSIONS: Both WFO and WFG PRK using a Schwind Amaris 750S laser for low to moderate myopia were safe and effective at improving visual and refractive outcomes. However, WFG PRK induced fewer spherical aberrations than WFO PRK and may be more advantageous for eyes with high HOA root mean square or spherical aberration. PMID: 32495529 [PubMed - in process]
Source: Korean Journal of Ophthalmology : KJO - Category: Opthalmology Tags: Korean J Ophthalmol Source Type: research
Conclusions: The presence of metabolic risk in children and adolescents was associated with low levels of cardiorespiratory fitness, independent of screen time, in an isolated or clustered manner.RESUMO Objetivo: Verificar a associa ção entre tempo de tela e aptidão cardiorrespiratória, de forma isolada e agrupada, e a presença de risco metabólico em escolares. Métodos: Estudo transversal com 1.200 escolares de Santa Cruz do Sul (RS). Foram avaliados o tempo de tela e a aptidão cardiorrespiratória. Foi calculado o es core de risco metabólico por meio da ...
Source: Revista Paulista de Pediatria - Category: Pediatrics Source Type: research
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