The addition of interstitial needles to intracavitary applicators in the treatment of locally advanced cervical cancer: Why is this important and how to implement in low- and middle-income countries?

Cervical cancer is the leading cause of cancer mortality of women in low-/middle-income countries. Interstitial needles improve outcomes but require resources beyond those available in endemic regions. We conducted a retrospective review of the use of interstitial needles in locally advanced cervical cancer and simulated both 3D planning without needles and 2D planning to explore the benefit of interstitial needles.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research

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Cancer of the uterine cervix is among the most preventable human malignancies, yet it remains a leading cause of death among women worldwide, accounting for more than 300  000 deaths annually. Well on its way to elimination in the global north, cervical cancer mostly affects women living in low- or middle-income countries (LMICs), where limited access to vaccination, screening, and therapy have made it overwhelmingly a disease of women who are poor and lack access to health care. Nowhere is this more evident than in sub-Saharan Africa, where HIV is endemic and where cervical cancer has surpassed breast cancer as the most...
Source: JAMA - Category: General Medicine Source Type: research
This article summarizes the recent advances in research on the multifarious pharmacological effects of A. camphorata. The mushroom exhibits anticancer activity toward a large variety of cancers including breast, cervical, ovarian, prostate, bladder, colorectal, pancreatic, liver, and lung cancers; melanoma; leukemia; lymphoma; neuroblastoma; and glioblastoma. Other activities encompass antiinflammatory, antiatopic dermatitis, anticachexia, immunoregulatory, antiobesity, antidiabetic, antihyperlipidemic, antiatherosclerotic, antihypertensive, antiplatelet, antioxidative, antiphotodamaging, hepatoprotective, renoprotective, ...
Source: Applied Microbiology and Biotechnology - Category: Microbiology Authors: Tags: Appl Microbiol Biotechnol Source Type: research
A young boy in Pakistan receives an oral polio vaccine (OPV). Over the last 30 years huge progress has been made against polio and it is now only endemic in 2 countries, Afghanistan and Pakistan, with only 33 cases confirmed cases last year. Credit: Ashfaq Yusufzai/IPSBy Tharanga YakupitiyageUNITED NATIONS, May 1 2019 (IPS) Since the introduction of vaccines, diseases such as measles and polio were quickly becoming a thing of the past. However, the world’s progress on immunisation is now being threatened. According to the World Health Organisation (WHO), 85 percent of the world’s children received basic va...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Featured Global Headlines Health IPS UN: Inside the Glasshouse North America Population Regional Categories TerraViva United Nations diptheria-tetanus-pertussis (DTP) human papillomavirus (HPV) Measles Vaccines World Health Organ Source Type: news
Mark K. Slifka1* and Ian J. Amanna2 1Division of Neuroscience, Oregon National Primate Research Center, Oregon Health &Science University, Beaverton, OR, United States2Najít Technologies, Inc., Beaverton, OR, United States Vaccines play a vital role in protecting our communities against infectious disease. Unfortunately, some vaccines provide only partial protection or in some cases vaccine-mediated immunity may wane rapidly, resulting in either increased susceptibility to that disease or a requirement for more booster vaccinations in order to maintain immunity above a protective level. The durability of a...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusion: In this study, no correlation between EBV and thyroid diseases was found in a cohort from southern China. Introduction Epstein-Barr virus (EBV) is a well-known human tumor virus with a very high prevalence in the population, especially for children and youth. EBV serum (IgG) is positive in an estimated 95% of the world's population (1). EBV infection is associated with epithelial and lymphoid malignancies, including nasopharyngeal carcinoma (NPC), gastric cancer, Hodgkin's lymphoma and Burkitt's lymphoma (2, 3). Although EBV has B-lymphocyte tropism, it can also infect T lymphocy...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionEven in a limited series, our data suggested that SUVmax, SUVmean and TLG of primary tumor could predict a poor outcome in NPC patients also in non-endemic area hypothesizing their use for refinement of prognostication.
Source: La Radiologia Medica - Category: Radiology Source Type: research
We examined epigenetic alterations, DNA methylation and microRNA dysregulation, in Epstein-Barr virus-related nasopharyngeal carcinoma in the endemic area of Southern China and found several differentially methyl ated tumor suppressor gene candidates by using a next-generation sequencer. Among these candidates, we revealed higher methylation rates of RAS-like estrogen-regulated growth inhibitor (RERG) in biopsy specimens of nasopharyngeal carcinoma more conveniently by using restriction enzyme-based real-tim e PCR. This result may help to improve cancer screening strategies. We profiled microRNAs of nasopharyngeal carcinom...
Source: Environmental Health and Preventive Medicine - Category: Environmental Health Source Type: research
There’s a very big difference between simple and easy—especially when it comes to global health. It’s simple to eradicate polio—just get all children are vaccinated. It’s simple to reduce nighttime malaria infections—make sure everyone in malaria-endemic areas sleeps under a bed net. But none of that is easy. The tension between simple and easy is at play when it comes to eradicating poverty in the developing world too, as the Bill &Melinda Gates Foundation makes clear in its second annual Goalkeepers Data Report. In a conversation with TIME, Bill Gates points to two recent waves of ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized onetime public health Source Type: news
A young boy from the Philippines with leprosy. The chronic disease is curable, and if treated in time disabilities related to the disease can be averted. Courtesy: moyerphotos/CC By 2.0By Elisio MuchangaMAPUTO, Jul 30 2018 (IPS)In the first six months of this year, the southern African nation of Mozambique has already registered 300 more cases of leprosy, some 951 cases, than it registered for the whole of 2017.The country, which had previously eliminated the chronic disease in 2008, is receiving funding from the Nippon Foundation—a non-profit philanthropic organisation from Japan that is active in many countrie...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Africa Development & Aid Featured Headlines Health Population Poverty & SDGs Regional Categories TerraViva United Nations Nippon Foundation Source Type: news
World Health Organization goodwill ambassador for Leprosy Elimination and chair of the Nippon Foundation, Yohei Sasakawa (left), holds the hand of a leprosy patient. Sasakawa visited Mozambique’s rural Namaita Centre to assess the progress of leprosy patients. The Nippon Foundation has been providing funds and medication in order to eliminate leprosy in Mozambique. Credit: Elísio Muchanga/IPSBy Elisio MuchangaNAMPULA PROVINCE, Mozambique, Jul 28 2018 (IPS)It takes Faurito António, 42, from Lalaua district, Nampula Province, two hours to reach his nearest health centre in order to receive the drugs neces...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Africa Development & Aid Editors' Choice Featured Headlines Health Population Poverty & SDGs Regional Categories TerraViva United Nations Nippon Foundation Source Type: news
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