Immune response and protective efficacy of intramuscular and intradermal vaccination with porcine reproductive and respiratory syndrome virus 1 (PRRSV-1) modified live vaccine against highly pathogenic PRRSV-2 (HP-PRRSV-2) challenge, either alone or in combination with of PRRSV-1

Publication date: Available online 27 March 2020Source: Veterinary MicrobiologyAuthor(s): Adthakorn Madapong, Kepalee Saeng-chuto, Puwich Chaikhumwang, Angkana Tantituvanont, Kriangsak Saardrak, Rafael Pedrazuela Sanz, Joel Miranda Alvarez, Dachrit Nilubol
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research

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Karniychuk We studied whether cytosine phosphate–guanine (CpG) recoding in a viral genome may provide oncolytic candidates with reduced infection kinetics in nonmalignant brain cells, but with high virulence in glioblastoma stem cells (GSCs). As a model, we used well-characterized CpG-recoded Zika virus vaccine candidates that previously showed genetic stability and safety in animal models. In vitro, one of the CpG-recoded Zika virus variants had reduced infection kinetics in nonmalignant brain cells but high infectivity and oncolytic activity in GSCs as represented by reduced cell proliferation. The recoded...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation. Lin28 as a Target for Nerve Regeneration Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitoch...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The objective of the present study was to elucidate the effect ofB. subtilis spores as adjuvants in chickens administered inactivated avian influenza virus H9N2. Herein, the adjuvanticity ofB. subtilis spores in chickens was demonstrated by enhancement of H9N2 virus-specific IgG responses.B. subtilis spores enhanced the proportion of B cells and the innate cell population in splenocytes from chickens administered both inactivated H9N2 andB. subtilis spores (Spore  + H9N2). Furthermore, the H9N2 and spore administration induced significantly increased expression of the pro-inflammatory cytokines IL-1β and...
Source: Veterinary Research - Category: Veterinary Research Source Type: research
AbstractBrucellosis is a neglected zoonosis. It causes acute febrile illness and a potentially debilitating chronic infection in humans, and livestock infection has substantial socioeconomic impact. Over the past two decades, improvements have been made to better understand the various aspects of human and animal brucellosis. Meanwhile, especially in the developing world, immense challenges that remain in controlling and eradicating brucellosis are novel diagnostics tools and efficacious vaccines. Here, we will focus on the remarkable issues on epidemiological survey, as well as the priority and challenge of brucellosis in...
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
CONCLUSIONS AND CLINICAL RELEVANCE: A method was established in rabbits for evaluation of the efficacy of a CSFV subunit vaccine that could help in the optimization of later large-scale vaccine production and quality control processes as well as in the clinical application of the vaccine. PMID: 32436789 [PubMed - in process]
Source: American Journal of Veterinary Research - Category: Veterinary Research Authors: Tags: Am J Vet Res Source Type: research
Vaccination is the act of administering a vaccine, whereas immunization may occur if appropriate time is allowed for a competent host immune system to respond to the antigen contained in a vaccine. Timing is critical to ensure bovine respiratory disease (BRD) vaccine safety, efficacy, and efficiency. The current review provides temporal considerations of BRD vaccination within the North American beef production system with focus on vaccination timing in high-risk, newly received beef stocker and feedlot cattle.
Source: Veterinary Clinics of North America: Food Animal Practice - Category: Veterinary Research Authors: Source Type: research
Vaccination of cattle against viral respiratory pathogens to minimize losses associated with bovine respiratory disease (BRD) is a common practice among producers and veterinarians. Three different calf populations in which BRD is most prevalent (recently weaned beef calves, preweaning beef calves, and young dairy calves) are the principal focus of morbidity and mortality prevention through vaccination; however, the evidence of vaccination efficacy is inconsistent in the literature. This review addresses the evidence of efficacy of vaccination in the prevention or reduction of naturally occurring and experimentally induced...
Source: Veterinary Clinics of North America: Food Animal Practice - Category: Veterinary Research Authors: Source Type: research
Advances in viral detection in bovine respiratory disease (BRD) have resulted from advances in viral sequencing of respiratory tract samples. New viruses detected include influenza D virus, bovine coronavirus, bovine rhinitis A, bovine rhinitis B virus, and others. Serosurveys demonstrate widespread presence of some of these viruses in North American cattle. These viruses sometimes cause disease after animal challenge, and some have been found in BRD cases more frequently than in healthy cattle. Continued work is needed to develop reagents for identification of new viruses, to confirm their pathogenicity, and to determine ...
Source: Veterinary Clinics of North America: Food Animal Practice - Category: Veterinary Research Authors: Source Type: research
Publication date: Available online 22 May 2020Source: BiologicalsAuthor(s): Nathalia S. Machado, Wildeberg C. Moreira, Jessica F. de S. Freitas, Antonio Eugenio C C de Almeida, Wlamir Correa de Moura
Source: Biologicals - Category: Biology Source Type: research
Publication date: Available online 19 May 2020Source: Veterinary MicrobiologyAuthor(s): Bao-Yang Ruan, Yun Yao, Shuai-Yong Wang, Xiao-Qian Gong, Xiao-Min Liu, Qi Wang, Ling-Xue Yu, Shi-Qiang Zhu, Juan Wang, Tong-Ling Shan, Yan-Jun Zhou, Wu Tong, Hao Zheng, Guo-Xin Li, Fei Gao, Ning Kong, Hai Yu, Guang-Zhi Tong
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
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