Comparative study of the chemical profile of the parotoid gland secretions from Rhaebo guttatus from different regions of the Brazilian Amazon.

Comparative study of the chemical profile of the parotoid gland secretions from Rhaebo guttatus from different regions of the Brazilian Amazon. Toxicon. 2020 Mar 21;: Authors: de Souza EBR, de Sousa Júnior PT, de Vasconcelos LG, de Jesus Rodrigues D, Sinhorin VDG, Kerkhoff J, do Nascimento Pelissari SR, Sinhorin AP Abstract Amphibian cutaneous secretion has great potential for bioprospection and is a great tool in the development of bioproducts. Thus, the objective of the present work was to evaluate the comparative study of thechemical profile parotoid gland secretions from Rhaebo guttatus collected in two distinct regions of the Brazilian Amazon. For this, the chemical composition of six methanolic extracts of this species were analyzed by Liquid Chromatography in UV and MS Detection Ultra-Chromatography Systems (UFLC-DAD-micrOTOF). All obtained chromatograms presented two distinct regions; one referring to the more hydrophilic molecules (alkaloids), while the other refers to the more hydrophobic compounds (steroids). The steroid region resembles all samples, regardless of where they were collected. In the alkaloid region, there was a standardized variation for the samples from the southern Brazilian Amazon, but the same was not true for the samples collected in the Amazon-Cerrado transition region. Thus, the data suggest that the environment and diet of R. guttatus may be important in alkaloid production, but do not influence ste...
Source: Toxicon - Category: Toxicology Authors: Tags: Toxicon Source Type: research