Time-Dependent Cytotoxic Properties of Terpyridine-Based Copper Complexes.

Time-Dependent Cytotoxic Properties of Terpyridine-Based Copper Complexes. Chembiochem. 2020 Mar 24;: Authors: Grau J, Caubet A, Roubeau O, Montpeyó D, Lorenzo J, Gamez P Abstract Five copper complexes supported by terpyridine ligands were prepared and characterized, viz . [Cu 3 Cl 4 ( Naphtpy ) 2 ][CuCl 2 ] ( 1 ), [Cu 2 Cl 2 ( Naphtpy ) 2 ](ClO 4 ) 2 ( 2 ), [CuCl 2 ( Naphtpy )] 2 (MeOH) 3 (H 2 O) ( 3 ), [CuCl 2 ( Cltpy )] ( 4 ) and [Cu( Cltpy ) 2 ](ClO 4 ) 2 ( 5 ); (where Naphtpy stands for 4'-((naphthalen-2-yl)methoxy)-2,2':6',2''-terpyridine and Cltpy for 4'-chloro-2,2':6',2''-terpyridine). Their DNA-interaction abilities were investigated, and their cytotoxic behaviors were examined with three cells lines, namely with human ovarian carcinoma cells (A2780) and its derived cisplatin-resistant line (A2780cis), and human cervix adenocarcinoma cells (HeLa). All compounds show good cytotoxic properties (especially after 72 h incubation). Remarkably, two compounds, i.e. 4 and 5 , are almost inactive after 24 h (particularly 4 ), but are highly active after 72 h, with IC 50 values in the low micromolar to submicromolar range. Compounds 1 and 2 induce necrosis, whereas late apoptosis is observed with 3 - 5 , 4 exhibiting a behaviour close to that of cisplatin. PMID: 32212203 [PubMed - as supplied by publisher]
Source: Chembiochem - Category: Biochemistry Authors: Tags: Chembiochem Source Type: research