Ruthenium(II)-Catalyzed Double Annulation of Quinones: Step-Economical Access to Valuable Bioactive Compounds.

Ruthenium(II)-Catalyzed Double Annulation of Quinones: Step-Economical Access to Valuable Bioactive Compounds.
Chemistry. 2020 Mar 25;:
Authors: da Silva Júnior EN, de Carvalho RL, Almeida RG, Rosa LG, Fantuzzi F, Rogge T, Costa PMS, Pessoa C, Jacob C, Ackermann L
Abstract
Double ruthenium(II)-catalyzed alkyne annulations of quinones were accomplished. Thus, we report a strategy that provides step-economical access to valuable quinones with a wide range of applications. C-H/N-H activations for alkyne annulations of naphthoquinones provided challenging polycyclic quinoidal compounds by forming four new bonds in one step. The singular power of the thus-obtained compounds was reflected by their antileukemic activity.
PMID: 32212283 [PubMed - as supplied by publisher]

Source: Chemistry - March 24, 2020 Category: Chemistry Authors: da Silva Júnior EN, de Carvalho RL, Almeida RG, Rosa LG, Fantuzzi F, Rogge T, Costa PMS, Pessoa C, Jacob C, Ackermann L Tags: Chemistry Source Type: research