Ruthenium-Catalyzed Site-Selective Trifluoromethylations and (Per)Fluoroalkylations of Anilines and Indoles.

Ruthenium-Catalyzed Site-Selective Trifluoromethylations and (Per)Fluoroalkylations of Anilines and Indoles.
Chemistry. 2020 Mar 26;:
Authors: Li Y, Neumann H, Beller M
Abstract
Introducing (per)fluoroalkyl groups into arenes continues to be an interesting, but challenging area in organofluorine chemistry. We herein report a novel ortho-selective C-H perfluoroalkylation including trifluoromethylations of anilines and indoles without the need of protecting groups using R f I and R f Br as commercially available reagents. The availability and price of the starting materials as well as the inherent selectivity make this novel methodology attractive for the synthesis of diverse (per)fluoroalkylated building blocks, e.g. for bio-active compounds and materials.
PMID: 32216068 [PubMed - as supplied by publisher]

Source: Chemistry - March 25, 2020 Category: Chemistry Authors: Li Y, Neumann H, Beller M Tags: Chemistry Source Type: research