Oral Azacitidine and Cedazuridine Approximate Parenteral Azacitidine Efficacy in Murine Model

ConclusionsWe conclude that oral AZA when combined with CDZ achieves successful tumor regression in both CDX and PDX models. Furthermore, the combination of AZA  + CDZ with VEN in a PDX model emulated responses seen with VEN + AZA in the clinic, implying a potential all-oral VEN-based therapy opportunity in myeloid diseases.
Source: Targeted Oncology - Category: Cancer & Oncology Source Type: research