French recommendations for the management of patients with spinal cord injury or at risk of spinal cord injury

Publication date: Available online 27 March 2020Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): A. Roquilly, B. Vigué, M. Boutonnet, P. Bouzat, K. Buffenoir, E. Cesareo, A. Chauvin, C. Court, F. Cook, A.C. de Crouy, P. Denys, J. Duranteau, S. Fuentes, T. Gauss, T. Geeraerts, C. Laplace, V. Martinez, J.F. Payen, B. Perrouin-Verbe, A. Rodrigues
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research

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Authors: Abstract Approximately 17,730 new spinal cord injuries (SCIs) occur per year in the United States. Effective rehabilitation and modern reproductive technology may increase the number of these patients considering pregnancy. Obstetrician-gynecologists and other obstetric care professionals who care for such patients should be familiar with problems related to SCIs that may occur throughout pregnancy and during the postpartum period. Autonomic dysreflexia (sometimes called autonomic hyperreflexia) is the most serious medical complication that occurs in women with SCIs and is found in 85% of patients with l...
Source: Obstetrics and Gynecology - Category: OBGYN Tags: Obstet Gynecol Source Type: research
Authors: Abstract Approximately 17,730 new spinal cord injuries (SCIs) occur per year in the United States. Effective rehabilitation and modern reproductive technology may increase the number of these patients considering pregnancy. Obstetrician-gynecologists and other obstetric care professionals who care for such patients should be familiar with problems related to SCIs that may occur throughout pregnancy and during the postpartum period. Autonomic dysreflexia (sometimes called autonomic hyperreflexia) is the most serious medical complication that occurs in women with SCIs and is found in 85% of patients with l...
Source: Obstetrics and Gynecology - Category: OBGYN Tags: Obstet Gynecol Source Type: research
We examined the expression of TRPV1 in peripheral tissue and DRG neurons of CPIP model rats and we studied whether CPIP model could induce peripheral sensitization of TRPV1 channel and enhance DRG neuron excitability. Then we examined the therapeutic effects of locally applied TRPV1 specific antagonist AMG9810 on pain responses of CPIP model rats. Lastly, we explored the effects of AMG9810 on DRG neuron hyperexcitability and spinal glial activation induced by CPIP. Our results demonstrate that TRPV1 plays an important role in mediating the behavioral hypersensitivity of CPIP model rats via promoting peripheral nociceptor a...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion: These findings support the hypothesis that in FM a deteriorated function of cortical inhibition, indexed by a higher SICI parameter, a lower function of the DPMS, together with a higher level of BDNF indicate that FM has different pathological substrates from depression. They suggest that an up-regulation phenomenon of intracortical inhibitory networks associated with a disruption of the DPMS function occurs in FM. Introduction Major depressive disorder (MDD) and fibromyalgia (FM) present overlapped symptoms. Although the connection between these two disorders has not been elucidated yet, the disruption...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Conclusion: The present study suggests that the extract of LMZ attenuates CFA-induced inflammatory pain by suppressing the ERK1/2 and NF-κB signaling pathway at both peripheral and central level. Introduction Pain is one of the most common symptoms in clinical practice, and inflammatory pain is the most important type of pain (Patapoutian et al., 2009). Inflammatory pain is a growing global health problem. In generally, there is a common course of progression in inflammation and pain share. When patients experience inflammation, they may develop hyperalgesia or allodynia to various mechanical, thermal, or che...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This study not only provides biological evidence to support the use of duloxetine as the first standard CIPN drug but will also lead to potential new targets for CIPN drug development. Introduction A major dose-limiting complication of chemotherapy is chemotherapy-induced peripheral neuropathy (CIPN). The greatest contributors to CIPN are taxanes (e.g., paclitaxel) and platinum-based (e.g., oxaliplatin) treatments (Krukowski et al., 2015). Paclitaxel (PTX) can effectively treat several of the most common cancers including breast cancer, lung cancer, and ovarian cancer (Ewertz et al., 2015; Cetinkaya-Fisgin et al., ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Editor ’s PerspectiveWhat We Already Know about This TopicOpiates, including morphine, remain a key component in the management of postsurgical pain; however, perioperative use of opiates is associated with a slower resolution of pain and functional statusIt is possible that the delayed recovery attendant with the administration of morphine may be attributable to morphine-induced enhancement of neuroinflammationWhat This Article Tells Us That Is NewIn a mouse tibia fracture and intramedullary pinning model, injury-induced allodynia and neuroinflammation, in particular microglial activation, were significantly increas...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
Traumatic spinal cord injury (SCI) results in loss of sensorimotor functions below the level of injury besides other secondary complications such as pain. However, regardless of many efforts, management of the SCI patients is difficult. In the present study, we used a non-invasive and easy to implement extremely low-frequency electromagnetic field (ELF-EMF; 50 Hz, 17.96 μT) technique to stimulate whole body after SCI. Laminectomy was performed at T10-12 vertebrae (Sham group) in anesthetized adult male rat followed by complete transection of the spinal cord at T11 vertebra and then half of the rats were subsequently exp...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research
As a shadowing medical student in family medicine clinics in Toronto, I’d seen patients with chronic pain of a neurogenic origin and always felt heartbroken. I’d looked on in helplessness as we consoled the patients and offered them physi...
Source: Medgadget - Category: Medical Devices Authors: Tags: Anesthesiology Exclusive Pain Management Rehab Source Type: blogs
Bioness, a Valencia, California medical device/rehabilitation company, recently received approval from Health Canada for its StimRouter device, an implantable peripheral nerve stimulator designed to reduce chronic pain. We spoke with Mark Geiger, the...
Source: Medgadget - Category: Medical Devices Authors: Tags: Anesthesiology Exclusive Neurosurgery Pain Management Source Type: blogs
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