The role of PTH during pregnancy on the relationship between maternal vitamin D deficiency and foetal growth restriction: a prospective birth cohort study.

The role of PTH during pregnancy on the relationship between maternal vitamin D deficiency and foetal growth restriction: a prospective birth cohort study. Br J Nutr. 2020 Mar 26;:1-32 Authors: Meng DH, Zhang Y, Hu HL, Li JJ, Yin WJ, Ma SS, Tao RX, Zhu P Abstract Previous studies have shown conflicting findings regarding the relationship between maternal vitamin D deficiency (VDD) and foetal growth restriction (FGR). We hypothesized that parathyroid hormone (PTH) may be an underlying factor relevant to this potential association. In a prospective birth cohort study, descriptive statistics were evaluated for the demographic characteristics of 3407 pregnancies in the second trimester from three antenatal clinics in Hefei, China. The association of the combined status of VD and PTH with birth weight and the risk of small for gestational age (SGA) was assessed by a multivariate linear and binary logistic regression. We found that declined status of 25(OH) D are associated with the lower birth weight (for moderate VDD : adjusted β=-49.4 g, 95% CI: -91.1, -7.8, P
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research

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This study is to evaluate the prevalence of vitamin D deficiency among pregnant women in Shanghai, China and to analyze the association of vitamin D status with some pregnancy outcomes (gestational diabetes and low birth weight).MethodsA total of 34,417 pregnant women in Shanghai were included in this study from January 2014 to December 2017, and the serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured at 16th week of gestation by electrochemiluminescence assay. Seventy five grams of glucose was used to conduct oral glucose tolerance test during 24-28th week of gestational in all enrolled persons and the birth ...
Source: Archives of Public Health - Category: International Medicine & Public Health Source Type: research
Conditions:   COVID;   Zinc Deficiency;   Vitamin D Deficiency Intervention:   Other: Serum zinc, vitamin d vitamin b12 levels . Sponsors:   Kanuni Sultan Suleyman Training and Research Hospital;   Ayşegül Bestel;   İbrahim Polat;   Merve Aldıkaçtıoğlu Talmaç Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Amouzegar A, Azizi F, Ashrafivand S, Ahi Z, Saleh M, Mohaghegh S, Gargari SS Abstract BACKGROUND: Calcium and vitamin D deficiency is common among Iranian women of childbearing age and poses adverse effects on pregnancy outcomes. The aim of the current study was to determine the prevalence of vitamin D and calcium in a sample of Iranian pregnant women and to assess its correlation with the feto-maternal outcomes. With this aim. METHODS: In this prospective cross-sectional study, a sample of pregnant women between 15 to 45 years who were in the third trimester were recruited from a number of hospitals i...
Source: Human Antibodies - Category: Biochemistry Tags: Hum Antibodies Source Type: research
This study aimed to explore the association of serum 25 ‐hydroxyvitamin D (25OHD) levels and semen parameters, as well as ART outcomes for men from infertile couples.Materials and MethodsThis study recruited 1,308 men from infertile couples who attended the Reproductive Medicine Center of Peking University Third Hospital for first time from February to August 2019(NCT03804294). Reproductive hormones levels, semen parameters and clinical outcomes of ART were compared between vitamin D deficient group (serum 25OHD ≤10 ng/mL), insufficient group (serum 25OHD 10‐20 ng/mL) and sufficient group (serum 25OHD≥20 ng/mL).R...
Source: Andrology - Category: Urology & Nephrology Authors: Tags: ORIGINAL ARTICLE Source Type: research
In conclusion, there is a high prevalence of vitamin D insufficiency among Malaysian pregnant women, but it is not associated with adverse maternal and neonatal outcomes. More comprehensive studies should be planned to verify this relationship.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Abstract There is evidence that mental health disorders may have roots in fetal life and are associated with deficiencies in various micronutrients, including vitamin D. During pregnancy, vitamin D homeostasis is influenced by an increase in maternal calcitriol and a substantial increase in maternal Vitamin D Binding Protein concentrations. In the early stages of life, vitamin D is necessary to mediate numerous brain processes such as proliferation, apoptosis, and neurotransmission. Furthermore, Vitamin D has a recognized anti-inflammatory activity that normally suppresses inflammation. Increased activation of hyp...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
Purpose: To examine if vitamin D deficiency was associated with poor sleep quality in a sample of African American and Hispanic pregnant women. We also examined if race moderates the relationship between serum 25(OH)D levels and sleep quality among participants in this sample. Study Design and Methods: Using a cross-sectional design, a sample of 115 African American and Hispanic pregnant women were enrolled from a federally qualified health center in the Midwest. Women completed questionnaires and had blood drawn for serum 25(OH)D levels between 24- and 32 weeks gestation. The questionnaires included demographic chara...
Source: MCN: The American Journal of Maternal Child Nursing - Category: Nursing Tags: Feature Source Type: research
Abstract Vitamin D is a neurosteroid hormone crucially involved in neurodevelopment. Neural cell proliferation, neurotransmission, oxydative stress and immune function, represent the main mechanisms mediated by vitamin D in the Central Nervous System. Therefore, its deficiency during pregnancy and early childhood may significantly impact on a developing brain, leading to possible adverse neuropsychological outcomes including Autism Spectrum Disorder (ASD). Significant vitamin D deficiency is described within children affected by ASD and in pregnant mothers whose offspring will later develop ASD, suggesting a possi...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
CONCLUSIONS: Maternal vitamin D deficiency increased intestinal permeability and decreased tight junction protein expression in offspring. The suppression of the Wnt/β-catenin signaling pathway through histone modification might be involved in the underlying mechanism. PMID: 32270535 [PubMed - as supplied by publisher]
Source: JPEN Journal Of Parenteral And Enteral Nutrition - Category: Nutrition Authors: Tags: JPEN J Parenter Enteral Nutr Source Type: research
Conditions:   Vitamin D Deficiency;   Immunosuppression Interventions:   Diagnostic Test: Microscopy ( Urine filtration), UCAA test, qPCR,;   Diagnostic Test: Microscopy (Kato Katz, Coproculture, Harada Mori, MIF), qPCR, Sponsors:   Centre de Recherche Médicale de Lambaréné;   Technische Universität München;   University Hospital Tuebingen Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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