C60 fullerenes increase the intensity of rotational movements in non ‑anesthetized hemiparkinsonic rats.

C60 fullerenes increase the intensity of rotational movements in non‑anesthetized hemiparkinsonic rats. Acta Neurobiol Exp (Wars). 2020;80(1):32-37 Authors: Maznychenko AV, Mankivska OP, Sokolowska Vereshchaka IV, Kopyak BS, Tomiak T, Bulgakova NV, Gonchar OO, Prylutskyy YI, Ritter U, Mishchenko IV, Kostyukov AI Abstract The effect of C60 fullerene aqueous colloid solution (C60FAS) on the intensity of long‑lasting (persisting for one hour) rotational movements in non‑anesthetized rats was investigated. For this purpose, an experimental hemiparkinsonic animal model was used in the study. Rotational movements in hemiparkinsonic animals were initiated by the intraperitoneal administration of the dopamine receptor agonist apomorphine. It was shown that a preliminary injection of C60FAS (a substance with powerful antioxidant properties) in hemiparkinsonic rats induced distinct changes in animal motor behavior. It was revealed that fullerene‑pretreated animals, in comparison with non‑pretreated or vehicle‑pretreated rats, rotated for 1 h at an approximately identical speed until the end of the experiment, whereas the rotation speed of control rats gradually decreased to 20-30% of the initial value. One can assume that the observed changes in the movement dynamics of the hemiparkinsonic rats after C60FAS pretreatment presumably can be induced by the influence of C60FAS on the dopaminergic system, although the isolated potentiati...
Source: Acta Neurobiologiae Experimentalis - Category: Neurology Authors: Tags: Acta Neurobiol Exp (Wars) Source Type: research