PD1/PD-L1 axis in uro-oncology.

PD1/PD-L1 axis in uro-oncology. Curr Drug Targets. 2020 Mar 26;: Authors: Junker K, Eckstein M, Fiorentino M, Montironi R Abstract The immune system is important to control tumor development and progression. However, tumor cells and cells of the tumor microenvironment can induce immune escape mechanisms including activation of immune checkpoints such as PD-1/PD-L1. Based on this knowledge, new immune therapies including PD-1 and PD-L1 inhibition have been developed and are already recommended as standard treatment in metastatic bladder and kidney cancer patients. In addition to its role as a therapeutic target PD-L1 seems to be a prognostic parameter although data are controversial. Only little is known about signaling pathways inducing PD-L1 expression in tumor cells on one hand and about its functional role for tumor cells itself. However, the understanding of the complex biological function of PD-L1 will improve therapeutic options in urological malignancies. This review is giving an overview of the current knowledge concerning the PD-1/PD-L1 axis in urological tumors including bladder, kidney, prostate, testicular and penile cancer. PMID: 32213156 [PubMed - as supplied by publisher]
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Targets Source Type: research

Related Links:

Tushar A Narain, Gagan Gautam, Amlesh Seth, Vikas K Panwar, Sudhir Rawal, Puneet Dhar, Harkirat S Talwar, Amitabh Singh, Jiten Jaipuria, Ankur MittalIndian Journal of Cancer 2020 57(2):129-138 The Corona Virus Disease-2019 (COVID-19), one of the most devastating pandemics ever, has left thousands of cancer patients to their fate. The future course of this pandemic is still an enigma, but health care services are expected to resume soon in a phased manner. This might be a long drawn process and we need to have policies in place, to be able to fight both, the SARS-CoV-2 virus and cancer, simultaneously, and emerge triumphan...
Source: Indian Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
Conclusion: This study can be taken as a small step toward making the registry of patients with urogenital tumors providing valuable information regarding the frequency, clinical presentation, and histological spectrum. Large population-based studies for a longer duration of time across both males and females are needed in the ever-changing trends of urogenital tumors.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
The prostate and bladder are the most common primary cancer sites for penile metastases. Here, we describe an unusual case of metastases from renal cell carcinoma to the penis discovered 1 month after nephrectomy in a 60-year-old man. The diagnosis was achieved using B-mode and contrast-enhanced ultrasound.
Source: Ultrasound Quarterly - Category: Radiology Tags: Correspondence Source Type: research
AbstractAimsTo investigate the role of Radiation Oncology in the management of genito-urinary (GU) cancer excluding prostate and penile cancer.MethodsThe questionnaire was focused on the evaluation of the degree of involvement of radiation oncologists in the work-up of bladder, renal cell carcinoma and testicular cancer (TC).ResultsEighty-eight radiation oncologists completed the survey. The majority (85.4%) of participating radiation oncologists were senior consultants (>  5 years of experience). Sixty-four (73.6%) carried out a multidisciplinary tumor board discussion of GU cases, while 23 (26.4%) did not....
Source: La Radiologia Medica - Category: Radiology Source Type: research
SummaryThe use of antiangiogenic agents in cancer therapy has become an attractive target in oncological research. However, concerning the uro-oncological field, current guidelines only recommend the use of antiangiogenic agents in metastatic renal cell cancer. Yet in recent years, several approaches for sequential treatment with angiogenesis inhibitors in other urogenital malignancies apart from renal cell cancer are ongoing. Thus, the present review article aims to provide an overview about clinical studies with antiangiogenic agents in prostate-, bladder-, testicular-, as well as penile cancer patients. For this, a &nbs...
Source: Memo - Magazine of European Medical Oncology - Category: Cancer & Oncology Source Type: research
Oncol Res Treat
Source: Oncology Research and Treatment - Category: Cancer & Oncology Source Type: research
Conclusion Dans notre centre, la mortalité spécifique reste élevée et les causes sont dominées par les cancers urologiques. Objective To identify the causes of deaths in a urology department of sub-Saharan Africa. Patients and Methods This is a retrospective study including all deaths between February 2010 and February 2014. The parameters studied were age at death, gender, co-morbidities, hospital stay and the cause of death. Results The number of deaths was 132 including 7 women and 125 men. Hospital mortality was 2.9%. The average age of deceased patients was 63,6 (median age 66). T...
Source: African Journal of Urology - Category: Urology & Nephrology Source Type: research
Cancer remains to be the second most common cause of death, and its incidence and mortality rates are increasing in China. According to the 2015 National Central Cancer Registry (NCCR) of China, the incidence of bladder cancer and prostate cancer ranked sixth and seventh, respectively, in male cancers. The majority of prostate cancer patients were diagnosed at an advanced stage. Early diagnosis of prostate cancer is the key to improve prostate cancer survival in China. Radical prostatectomy or radical radiotherapy is the main treatment for localized prostate cancer, and a comprehensive therapy based on androgen deprivation...
Source: Japanese Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Tags: Mini-Review Source Type: research
Conclusion Dans notre centre, la mortalité spécifique reste élevée et les causes sont dominées par les cancers urologiques. Objective To identify the causes of deaths in a urology department of sub-Saharan Africa. Patients and Methods This is a retrospective study including all deaths between February 2010 and February 2014. The parameters studied were age at death, gender, co-morbidities, hospital stay and the cause of death. Results The number of deaths was 132 including 7 women and 125 men. Hospital mortality was 2.9%. The average age of deceased patients was 63,6 (median age 66). T...
Source: African Journal of Urology - Category: Urology & Nephrology Source Type: research
Abstract: Benign prostatic hyperplasia (BPH) has been suggested to be a risk factor for certain urologic cancers, but the current evidence is inconsistent. The aim of this study was to investigate the association between BPH and urologic cancers. MEDLINE, EMBASE, Cochrane Library, and Web of Science were searched for potential eligible studies. We included case-control studies or cohort studies, which evaluated the association between BPH and urologic cancers (including prostate cancer, bladder cancer, kidney cancer, testicular cancer, or penile cancer). Overall effect estimates were calculated using the DerSimonian&nd...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Meta-Analysis of Observ Studies in Epidemiology Source Type: research
More News: Bladder Cancer | Cancer | Cancer & Oncology | Drugs & Pharmacology | Kidney Cancer | Penile Cancer | Urology & Nephrology