Effect of Metformin For Decreasing Proliferative Marker in Women with Endometrial Cancer: A Randomized Double-blind Placebo-Controlled Trial.

CONCLUSION: Short-term treatment with an oral metformin significantly reduced a proliferative marker Ki-67 index in women with endometrioid EC awaiting surgical staging. This study supports the biological effect of metformin in EC and potential applications in the adjuvant treatment in EC patients. PMID: 32212801 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

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Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases. Author Contributions All authors listed have made a substantial, direct and i...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
CONCLUSION: In addition to pharmacological interventions, long-term standardized individualized management of PCOS patients is needed to achieve fertility and reduce the risk of metabolic related diseases. PMID: 30706800 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
Conclusions: Consistent with previous literature, our analysis found that type 2 cancer is more common in non-white, older, and less obese patients and associated with higher mortality and recurrence. However, inconsistent with previous literature, we found no association between type 2 cancer and diabetes mellitus or use of HRT. These factors should be considered when approaching patients with endometrial cancer.Gynecol Obstet Invest
Source: Gynecologic and Obstetric Investigation - Category: OBGYN Source Type: research
Bisphenol-A (BPA), a prototype endocrine disrupting molecule, has been associated with many disease entities such as diabetes mellitus, obesity, polycystic ovarian disease, cardiovascular disease, reproductive and neurodevelopmental disorders. BPA has also been associated mainly with hormone sensitive cancers such as breast, prostate, endometrial, ovarian, testicular and thyroid cancers but also non-hormonal sensitive cancers such as cervical and lung cancers, osteosarcoma and meningioma. Recent research has investigated the sources of contamination which are responsible for higher BPA concentrations in the oral cavity and...
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
Most mainstream doctors believe that polycystic ovary syndrome, PCOS, is a disease. PCOS is, after all, associated with markedly increased risk for type 2 diabetes, hypertension, endometrial cancer, and heart disease, in addition to outward signs that include excessive facial and body hair, tendency to being overweight or obese, irregular menstrual cycles, infertility. A crisis of self esteem commonly and understandably results. Mainstream doctors tell you to not worry because they have plenty of prescription drugs to “treat” it, not to mention various hormones, fertility procedures, and gastric bypass. PCOS is...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates acne facial change facial hair gluten-free grain-free grains Inflammation pcos polycystic ovary testosterone undoctored Weight Loss wheat belly Source Type: blogs
Publication date: August 2018Source: Trends in Food Science &Technology, Volume 78Author(s): Nevin Sanlier, Buşra Basar Gokcen, Mehmet AltuğAbstractTea is the most widely consumed beverage in the world next to water and is obtained from the leaves Camellia sinensis. In recent years, the potential health benefits and effect mechanisms of tea have attracted a lot of interest. The potential health benefits of tea have been attributed to its various phenolic compounds with unique biological properties found in tea. These phenolic compounds are especially catechins and their derivatives, which constitute at most 30% of th...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
CONCLUSIONS: Our findings are inconclusive as to the possible effect of metformin on the prognosis of endometrioid EC in women with T2D. However, use of metformin may reduce mortality from other causes. PMID: 29054569 [PubMed - as supplied by publisher]
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Tags: Gynecol Oncol Source Type: research
This study has been limited for interpretation due to its small sample size and not being the primary focus of the original study.Coronal view showing bilateral polycystic ovaries.A more recent study compared separately the risk of PCOS and its relations to endometrial, ovarian, and breast cancers, which originally showed on analysis that ovarian cancer was not significant (OR 1.41;95% CI,0.93-2.15 p
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
AbstractPurposeObesity and diabetes (DM) are known to increase the risk of endometrial cancer (EC). However, little is known about the prevalence of abnormal glucose metabolism and insulin resistance (IR) in EC patients. We aimed to evaluate the prevalence of abnormal glucose metabolism and IR in EC patients.MethodsWe prospectively enrolled atypical endometrial hyperplasia (AEH) and EC patients who had received planned treatment at Chiba University Hospital, Japan. All patients, except those with a confirmed diagnosis of DM, underwent the 75-g oral glucose tolerance test (OGTT) before treatment. We evaluated the prevalence...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
ConclusionsHistories of hypertension, diabetes, and use of diuretics, beta blockers, insulin, and oral antidiabetic medications may influence the survival of ovarian cancer patients. Understanding mechanisms for these observations could provide insight regarding treatment.
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
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