A Prospective Study: Connection Between Vitamin D Level and the Efficacy of Dexamethasone in Immune Thrombocytopenia

Condition:   Immune Thrombocytopenia Intervention:   Drug: Dexamethasone Sponsor:   Shandong University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Worldwide use of pneumococcal conjugate vaccines (PCVs) had reduced the incidence of pneumonia and invasive pneumococcal disease (IPD) in children.1,2 Despite increasing vaccine coverage and a reduction in the prevalence of IPD, Streptococcus pneumoniae remains a significant cause of non-Shiga toxin-producing Escherichia coli hemolytic uremic syndrome (HUS) in children.3 HUS is characterized by the presence of the clinical triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Editorial Source Type: research
Publication date: 2020Source: IDCases, Volume 21Author(s): Sara Sadr, SeyedAhmad SeyedAlinaghi, Fereshteh Ghiasvand, Malihe Hassan Nezhad, Nina Javadian, Roghieh Hossienzade, Fatemeh Jafari
Source: IDCases - Category: Infectious Diseases Source Type: research
Publication date: Available online 29 May 2020Source: Blood Cells, Molecules, and DiseasesAuthor(s): Gardellini Angelo, Francesca Guidotti, Zancanella Michelle, Saccà Vittoria, Maddalena Feltri, Luciana Ambrosiani, Turrini Mauro
Source: Blood Cells, Molecules, and Diseases - Category: Hematology Source Type: research
Authors: Amgalan A, Othman M Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease in 2019 (COVID-19) which rapidly evolved from an outbreak in Wuhan, China into a pandemic that has resulted in over millions of infections and over hundreds of thousands of mortalities worldwide. Various coagulopathies have been reported in association with COVID-19, including disseminated intravascular coagulation (DIC), sepsis-induced coagulopathy (SIC), local microthrombi, venous thromboembolism (VTE), arterial thrombotic complications, and thrombo-inflammation. There is a...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
Abstract OBJECTIVE: To assess whether mild thrombocytopenia (platelet count 100-149 k/microliter) is associated with an increased risk of postpartum hemorrhage. METHODS: Nulliparous women with term, singleton, vertex pregnancies undergoing labor at our institution between August 2016 and September 2017 were included. The primary exposure was mild thrombocytopenia, defined as platelet count 100-149 k/microliter, and the comparator was normal platelet count (150 k/microliter or greater). Those with severe thrombocytopenia (platelet count less than 100 k/microliter) were excluded from analysis. The primary outco...
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
Abstract Patients with ventricular assist devices (VADs) and extracorporeal membrane oxygenation (ECMO) suffer from an increased risk for thromboembolic events as well as for hemorrhages. High shear stress in the mechanical device results in acquired von Willebrand syndrome (AVWS), characterized by a loss of high-molecular-weight multimers of von Willebrand factor (VWF) leading to an increased bleeding risk. Onset of AVWS occurs within hours, persists during the whole period of mechanical support, and subsides rapidly after explantation. Patients with the older HeartMate II exhibit more severe AVWS than those with...
Source: Hamostaseologie - Category: Hematology Authors: Tags: Hamostaseologie Source Type: research
Immune checkpoint inhibitors (ICIs) have shown antitumor activity against a wide variety of malignancies. The anti-PD antibody pembrolizumab has become a standard treatment for PD-L1-positive non-small cell lung cancer (NSCLC) patients. ICIs have hematological side effects called hematological immune-related adverse events (hem-irAEs), and ICI-induced immune-related thrombocytopenia is one of them [1]. Several reports have described the clinical course and management of ICI-induced immune-related thrombocytopenia in melanoma patients and NSCLC patients [2][3], but there has been little evidence regarding refractory ICI-ind...
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
This study provides useful details to benchmark a pivotal model of Lassa fever in support of medical countermeasure development for both endemic disease and traditional biodefense purposes.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Conclusion: Monocytopenia, especially anemia, was the most common type of cytopenia. The cytopenia was predominantly grade 2, developed in majority of the patients within 6 months after imatinib initiation, and had resolved by 24-36 months after imatinib initiation. PMID: 32454829 [PubMed]
Source: Advances in Hematology - Category: Hematology Tags: Adv Hematol Source Type: research
Alemtuzumab, a monoclonal antibody targeting CD52 that causes lymphocyte apoptosis, is a form of advanced immunosuppression that is currently used as a therapy for refractory acute cellular rejection and chronic lung allograft dysfunction in lung transplant recipients (1–3). Side effects of alemtuzumab include bone marrow suppression, infection, and malignancy. Whether alemtuzumab can be safely used in allograft recipients that have an increased propensity for bone marrow suppression due to telomeropathies is unknown. In a retrospective case series, we report outcomes associated with alemtuzumab in three lung allogra...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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