US biotech firm wants to test its pneumonia treatment in COVID-19 patients

BioAegis of New Jersey is developing a drug using gelsolin, a protein that helps to clear away inflammation from pneumonia, which is responsible for the deaths of coronavirus patients.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Conditions:   Pneumonia, Viral;   Corona Virus Infection Intervention:   Biological: Anti-coronavirus antibodies (immunoglobulins) obtained with DFPP form convalescent patients Sponsors:   Piero Luigi Ruggenenti;   Aferetica Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: SARS-Cov-2 has emerged as a worldwide threat, currently affecting 170 countries and territories across the globe. There is still much to be understood regarding SARS-CoV-2 about its virology, epidemiology and clinical management strategies; this knowledge will be essential to both manage the current pandemic and to conceive comprehensive measures to prevent such outbreaks in the future. PMID: 32495923 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Zou J, Song DW, Niu JJ, Shi JW, Yang HL Abstract Since the end of 2019, China and other regions around the world have been facing a pandemic of novel coronavirus pneumonia (COVID-19). The virus is highly transmissible, and the human population is generally susceptible. Most patients with osteoporosis are postmenopausal women or elderly people with hypoimmunity, so the osteoporosis clinic has become a new hotspot for corona virus infection. During the COVID-19 pandemic, it is necessary to establish standardized out-patient protocols to provide safe and effective treatment for osteoporosis patients and medic...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Ufuk F, SavaƟ R, Hazirolan T Abstract Dear editor, We read with great interest the article titled ?Radiological approaches to COVID-19 pneumonia? by Akcay S. et al. in the latest issue of Turk J Med Sci [1]. The authors provided a review of the radiological findings of novel coronavirus disease (COVID-19) pneumonia. We would like to highlight some missing radiological findings in this article, and we want to contribute to some critical radiological findings. PMID: 32490640 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
The respiratory condition COVID-19 arises in a human host upon the infection with SARS-CoV-2, a coronavirus that was first acknowledged in Wuhan, China, at the end of December 2019 after its outbreak of viral pneumonia. The full-blown COVID-19 can lead, in susceptible individuals, to premature death because of the massive viral proliferation, hypoxia, misdirected host immunoresponse, microthrombosis, and drug toxicities. Alike other coronaviruses, SARS-CoV-2 has a neuroinvasive potential, which may be associated with early neurological symptoms. In the past, the nervous tissue of patients infected with other coronaviruses ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusions: The possibility of severity in COVID-19 infection predicted by scoring system could help patients to receiving different therapy strategies at a very early stage.Topic: COVID-19, severe and fetal pneumonia, logistic regression, scoring system, prediction.
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
To investigate the feasibility of lung ultrasound in evaluating coronavirus disease 2019 (COVID-19) and distinguish the sonographic features between COVID-19 and community-acquired pneumonia (CAP), a total of 12 COVID-19 patients and 20 CAP patients were selected and underwent the lung ultrasound. Modified Buda scoring system for interstitial lung disease (ILD) was used to evaluate the severity and treatment effect of COVID-19 on ultrasonography. The differences between modified lung ultrasound (MLUS) score and high-resolution computed tomography (HRCT) Warrick score were analyzed to evaluate their correlation.
Source: Ultrasound in Medicine and Biology - Category: Radiology Authors: Source Type: research
Condition:   Coronavirus Infections Interventions:   Drug: Opaganib;   Drug: Placebo Sponsor:   RedHill Biopharma Limited Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
             Basel, 04 June 2020   - Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today that the U.S. Food and Drug Administration (FDA) has issued an Emergency Use Authorisation (EUA) for the Elecsys® IL-6 test. This test measures levels of the biomarker interleukin 6 (IL-6) and can be used to help identify patients with confirm ed COVID-19 disease who could be at high risk of intubation with mechanical ventilation. The test can support physicians, in combination with other examinations and vital signs, to decide early on if a patient with confirmed...
Source: Roche Media News - Category: Pharmaceuticals Source Type: news
This study provides the largest overview of autopsies of SARS-CoV-2-infected patients presented so far.
Source: International Journal of Legal Medicine - Category: Medical Law Source Type: research
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