Changes in Anti-JCV Antibody Status in a Large Population of Multiple Sclerosis Patients Treated with Natalizumab

ConclusionOur data confirmed that a high percentage of patients shift to or remain in a positive JCV status during NTZ treatment and after discontinuation. NTZ suspension seems not to be able to interfere on JCV status modification over an extended period. The choice of alternative treatment as exit strategy after NTZ discontinuation should be carefully considered because it could negatively influence the PML risk stratification of patients.
Source: CNS Drugs - Category: Neurology Source Type: research

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Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the CNS. Bile acids are cholesterol metabolites that can signal through receptors on cells throughout the body, including in the CNS and the immune system. Whether bile acid metabolism is abnormal in MS is unknown. Using global and targeted metabolomic profiling, we identified lower levels of circulating bile acid metabolites in multiple cohorts of adult and pediatric patients with MS compared with controls. In white matter lesions from MS brain tissue, we noted the presence of bile acid receptors on immune and glial cells. To mechanistically examine the ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Publication date: Available online 26 May 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): S. El-Wahsh, H. Bogaardt, F. Kumfor, K. Ballard
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 26 May 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Juan Zhang, Yong-Feng Xu, Lei Wu, Hong-Fu Li, Zhi-Ying Wu
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 25 May 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): A Droby, L Fleysher, M Petracca, K Podranski, J Xu, M Fabian, M MarjaĊ„ska, M Inglese
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 25 May 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Kejia Zhang, Yinlong Zhao, Zhenzhen Liang, Chunpeng Wang, Xin Liu
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 25 May 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Guillermo Delgado-García, Emmanuel Antonio-Luna, Diego López-Mena, Verónica Rivas-Alonso, José Flores-Rivera, Teresa Corona-Vázquez
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 25 May 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Soonwook Kwon, Ye Sel Kim, Juhyeon Kim, Byoung Joon Kim, Ju-Hong Min
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
CONCLUSIONS: Our study showed that IL1RAP rs4624606, IL-6 rs1800795, and HTRA1 rs11200638 are not associated with an increased risk of developing ON. However, the IL1RL1 rs1041973 A/C genotype might be associated with an increased risk of developing ON. PMID: 32449403 [PubMed - as supplied by publisher]
Source: Ophthalmic Genetics - Category: Opthalmology Tags: Ophthalmic Genet Source Type: research
TUESDAY, May 26, 2020 -- Air pollution might increase the risk for multiple sclerosis (MS), Italian researchers report. They found that in places with low levels of tiny particles of air pollution called particulate matter, the risk for MS was...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
EU-funded researchers are aiming to develop a new class of drugs to treat and even cure multiple sclerosis, building on groundbreaking research into previously unexploited mechanisms of an ancestral metabolic molecule the helps regulate the immune system of all humans and mammals.
Source: EUROPA - Research Information Centre - Category: Research Source Type: news
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