Atomoxetine Does Not Improve Complex Attention in Idiopathic Parkinson's Disease Patients with Cognitive Deficits: A Meta-Analysis.

Conclusion: In idiopathic PD with MCI, atomoxetine does not improve complex attention. Also, a deteriorative trend in the executive function was noted. PMID: 32211146 [PubMed]
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research

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Publication date: 6 June 2020Source: New Scientist, Volume 246, Issue 3285Author(s): Jessica Hamzelou
Source: New Scientist - Category: Science Source Type: research
PARKINSON'S disease is a condition whereby parts of the brain become progressively damaged over many years. Symptoms vary from person to person but one warning sign to watch out for can be seen in your handwriting.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra. However, other non-dopaminergic neuronal systems such as the serotonergic system are also involved. Serotonergic dysfunction is associated with non-motor symptoms and complications, including anxiety, depression, dementia, and sleep disturbances. This pathology reduces patient quality of life. Interaction between the serotonergic and other neurotransmitters systems such as dopamine, noradrenaline, glutamate, and GABA controls the activity of striatal neurons and are particularly interesting for understan...
Source: Frontiers in Neuroanatomy - Category: Neurology Source Type: research
Conclusion: Appendectomy and potentially also tonsillectomy were associated with a lower risk PD. A potential mechanism may involve surgical removal of alpha-synuclein redundancy in the appendix and tonsils.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Mitochondrial dysfunction is implicated in sporadic and familial Parkinson's disease (PD). However, the mechanisms that impair homeostatic responses to mitochondrial dysfunction remain unclear. Previously, we found that chronic, low-dose administration of the mitochondrial complex I inhibitor 1-methyl-4-phenylpyridinium (MPP+) dysregulates mitochondrial fission–fusion, mitophagy, and mitochondrial biogenesis. Given that PTEN-induced kinase 1 (PINK1) regulates mitochondrial function, dynamics, and turnover, we hypothesized that alterations in endogenous PINK1 levels contribute to depletion of mitochondria during chron...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Molecular Bases of Disease Source Type: research
In this study, we used a paracrine αsyn in vitro neuronal model to test the impact of Rab27b on αsyn release, clearance, and toxicity. shRNA-mediated knockdown (KD) of Rab27b increased αsyn-mediated paracrine toxicity. Rab27b reduced αsyn release primarily through nonexosomal pathways, but the αsyn released after Rab27b KD was of higher-molecular-weight species, as determined by size-exclusion chromatography. Rab27b KD increased intracellular levels of insoluble αsyn and led to an accumulation of endogenous light chain 3 (LC3)-positive puncta. Rab27b KD also decreased LC3 turnover after ...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Neurobiology Source Type: research
Sensors, Vol. 20, Pages 3216: Quantifying Spatiotemporal Gait Parameters with HoloLens in Healthy Adults and People with Parkinson’s Disease: Test-Retest Reliability, Concurrent Validity, and Face Validity Sensors doi: 10.3390/s20113216 Authors: Geerse Coolen Roerdink Microsoft’s HoloLens, a mixed-reality headset, provides, besides holograms, rich position data of the head, which can be used to quantify what the wearer is doing (e.g., walking) and to parameterize such acts (e.g., speed). The aim of the current study is to determine test-retest reliability, concurrent validity, and face validi...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Sensors, Vol. 20, Pages 3209: Muscle Synergies in Parkinson’s Disease Sensors doi: 10.3390/s20113209 Authors: Ilaria Mileti Alessandro Zampogna Alessandro Santuz Francesco Asci Zaccaria Del Prete Adamantios Arampatzis Eduardo Palermo Antonio Suppa Over the last two decades, experimental studies in humans and other vertebrates have increasingly used muscle synergy analysis as a computational tool to examine the physiological basis of motor control. The theoretical background of muscle synergies is based on the potential ability of the motor system to coordinate muscles groups as a single unit, th...
Source: Sensors - Category: Biotechnology Authors: Tags: Review Source Type: research
BackgroundDepression is the most common non-motor symptom in patients with Parkinson’s disease (PD) with unknown mechanisms, but the diagnostic criteria of PD with depression (PDD) are not uniform.PurposeThe aim of the study was to investigate interhemispheric interactions between PDD patients and patients with PD without depression (PDND).MethodsThe voxel-mirrored homotopic connectivity (VMHC) combined with the seed-based method was used to investigate intrinsic resting-state functional connectivity (RSFC) in 33 PDD patients, 60 PDND, and 47 healthy controls (HCs).ResultsPDD patients exhibited a decreased VMHC in th...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Condition:   Parkinson Disease Interventions:   Other: Game based treadmill Program;   Other: Conventional Gait Rehabilitation Sponsors:   University of Manitoba;   Weston Brain Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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