Chronic viral infections impinge on naive bystander CD8 T cells

ConclusionsOur results document numeric, phenotypic, and functional adaptation of bystander naive CD8 T cells during nonrelated chronic viral infection. Their functional impairment was only evident in the chronically infected host, indicating that T ‐cell extrinsic factors, in particular the quality of priming APCs, are responsible for the impaired function of naive bystander T cells in the chronically infected hosts.

Source: Immunity, Inflammation and Disease - March 28, 2020 Category: Allergy & Immunology Authors: Isabel Barnstorf, Suzanne P. M. Welten, Mariana Borsa, Nicolas S. Baumann, Katharina Pallmer, Nicole Joller, Roman Sp örri, Annette Oxenius Tags: ORIGINAL RESEARCH Source Type: research