Reduced regulatory T cells with increased proinflammatory response in patients with schizophrenia

AbstractAimTo investigate whether circulating T cells including regulatory T cells (Treg) and derived cytokines contribute to the immune imbalance observed in schizophrenia.MethodsForty patients with schizophrenia and 40 age, sex, body mass index, education, and smoking status –matched healthy controls (HC) are included in the study. We stained cells with anti-CD14, anti-CD3, anti-CD4, anti-CD8, anti-CD19, anti-CD20, and anti-CD16/56. Peripheral blood mononuclear cells (PBMCs) were isolated and stained with the human FoxP3 kit containing anti-CD4/anti-CD25 and intracell ular anti-Foxp3. PBMCs were cultured for 72 h and stimulated with anti-CD3/anti-CD28. Cytokines (IL-2, IL-4, IL-6, IL-10, IFN-γ, TNF-α, and IL-17A) were measured from the culture supernatant and plasma using the Th1/Th2/Th17 cytokine bead array kit.ResultsIn comparison with HC, Treg percentages in schizophrenia were higher (1.17  ± 0.63 vs 0.81 ± 0.53,P = 0.005) in unstimulated but lower in the stimulated condition (0.73 ± 0.69 vs 0.97 ± 0.55,P = 0.011). Activated T cell percentages were higher in schizophrenia than HC in unstimulated (2.22 ± 0.78 vs 1.64 ± 0.89,P = 0.001) and stimulated (2.25 ± 1.01 vs 1.72 ± 1.00,P  = 0.010) conditions. The culture supernatant levels ...
Source: Psychopharmacology - Category: Psychiatry Source Type: research

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Publication date: Available online 24 May 2020Source: European Journal of Integrative MedicineAuthor(s): Xiaotong Wang, Haixiong Lin, Kangju Li, Tao Huang, Xiumin Jiang, Shengwei Wu, Aixiang Xiao, Lin Yu, Yongjun Chen
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Authors: Styła R, Kowalski J Abstract OBJECTIVES: Measuring severity of psychopathological symptoms using self-assessment questionnaires is important for clinical and scientific research. However, there is no widely-available Polish tool which measures both overall functioning and severity of a broad spectrum of psychopathological symptoms. This paper describesthe designing of such a tool -the General Functioning Questionnaire (GFQ-58). METHODS: Three studies were conducted to verify the validity and reliability of the GFQ-58: (1)a study comparing 30 individuals diagnosed with schizophrenia and 30 with no psyc...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
Authors: Feng X, Jia Y, Cao X, Ji T, Zhao Y, Tian H, Li N, Cheng Z, Chen L Abstract Morita therapy was developed for common mental problems, and our aim was to evaluate the clinical effect of Morita therapy on schizophrenia. The literature was searched in 10 databases, namely, PubMed, Chinese National Knowledge Infrastructure (CNKI), Sinomed, Wanfang, Cochrane Library, UpToDate, Web of Science, Medline, PsycINFO and Embase, from inception to September 4, 2019. Random-effects models were used. For continuous results, the standardized mean differences (SMDs) and 95% confidence intervals (CIs) were calculated to synth...
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Symptoms of mental disorder, particularly schizophrenia, predispose tp victimazation. Much les is knows about the relationship between depressive symptpms and later vistimisation in the general population, the influence on types of subsequent victimazation...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Risk Factor Prevalence, Injury Occurrence Source Type: news
BACKGROUND: Childhood trauma is a risk factor for psychosis as well for violent behavior and offending later in life. Childhood trauma comprises subdomains of abuse and neglect that may be differently related to later violence among patients with schizophr...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Conditions:   Schizophrenia;   Parkinson Disease;   Hallucinations Intervention:   Sponsors:   University of Cambridge;   Cambridge University Hospitals NHS Foundation Trust;   Cambridgeshire and Peterborough NHS Foundation Trust Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: Trials of antidepressants may be driven mainly by commercial interests, focusing on prevalent diseases and everyday problems. No one can live a full life without experiencing several of the problems for which these drugs were tested. Antidepressants, sometimes called happy pills, could be seen as the modern version of Aldous Huxley's soma pill intended to keep everyone happy in the "Brave New World". PMID: 32444565 [PubMed - as supplied by publisher]
Source: International Journal of Risk and Safety in Medicine - Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research
Publication date: September 2020Source: Schizophrenia Research: Cognition, Volume 21Author(s): Sivan Regev, Naomi Josman
Source: Schizophrenia Research: Cognition - Category: Psychiatry Source Type: research
Publication date: Available online 23 May 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): E. De la Serna, P. Camprodon-Boadas, D. Ilzarbe, G. Sugranyes, I. Baeza, D. Moreno, C.M. Díaz-Caneja, M. Rosa-Justicia, C. Llorente, M. Ayora, R. Borras, C. Torrent, M. Bernardo, J. Castro-Fornieles
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
ObjectivesSchizophrenia (SZ) is a complex psychiatric disorder that has a strong genetic basis. Dystrobrevin-binding protein 1 (DTNBP1) is one of the genes thought to be pivotal in regulating the glutamatergic system. Studies have suggested that variations in DTNBP1 confer susceptibility to SZ and clinical symptoms. Here, we performed a two-stage independent verification study to identify polymorphisms of the DTNBP1 gene that might be associated with SZ in the Han Chinese population.MethodsIn stage 1, 14 single nucleotide polymorphisms (SNPs) were genotyped in 528 paranoid SZ patients and 528 healthy controls (HCs) using t...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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