Attention Deficit Hyperactivity Disorder Diagnosis using non-linear univariate and multivariate EEG measurements: a preliminary study

In this study we propose two classification algorithms for discriminating ADHD children from normal children using their resting state Electroencephalography (EEG) signals. One algorithm is based on the univariate features extracted from individual EEG recording channels and the other is based on the multivariate features extracted from brain lobes. We focused on entropy measures as non-linear univariate and multivariate features. Average power, Theta/Beta Ratio (TBR), Shannon Entropy (ShanEn), Sample Entropy (SampEn), Dispersion Entropy (DispEn) and Multiscale SampEn (MSE) were extracted as linear and non-linear univariate features. Besides, multivariate SampEn (mvSE) and multivariate MSE (mvMSE) were extracted as non-linear multivariate features. Classification was followed by three classifiers: Support Vector Machines (SVM) with different kernels, k-Nearest Neighbor (kNN) and Probabilistic Neural Network (PNN). Complexity analysis of multi-channel EEG data was performed using mvMSE approach. Entropy mapping as a useful tool was used to visually track changes of entropies in various brain regions. Based on achieved results, ADHD children have higher brain activity and TBR compared to normal children, while their neural system is more regular. Besides, ADHD children have reduced dynamical complexity of neural system. Finally, the accuracy of 99.58% was achieved in classification based on a combination of non-linear univariate features by Radial Basis Function (RBF) SVM. For ...
Source: Australasian Physical and Engineering Sciences in Medicine - Category: Biomedical Engineering Source Type: research

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Authors: Sagiadinou M, Plerou A Abstract Neurofeedback video games respond to electrical brain signals instead to a mouse, joystick, or game controller input. These games embody the concept of improving physiological functioning by rewarding specific healthy body signals with success at playing a video game. In this paper, a threefold framework in reference to attention deficit disorder (ADD) and attention deficit hyperactivity disorder (ADHD) treatment blending with neurofeedback techniques and video game implementation is presented. In particular, the specifications of a neurofeedback-based video game for childre...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Conclusions: Although these data suggest ADHD symptom and EF deficit improvement following lisdexamfetamine are interdependent, it is advantageous to use measures like the BRIEF-A to assess stimulant effects on the wide range of EF deficits associated with ADHD that are not captured by the ADHD-RS-AP alone. Trial Registration: Data used in this secondary analysis came from ClinicalTrials.gov identifier: NCT01101022. PMID: 32470230 [PubMed - as supplied by publisher]
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
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Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
AbstractPolypharmacy is common in the treatment of attention-deficit hyperactivity disorder (ADHD). However, the use of multiple drugs increases the risk of pharmacokinetic drug –drug interactions (DDIs) and subsequent adverse safety outcomes. Clinically relevant pharmacokinetic DDIs can be prevented by adjusting the dose of the ADHD drug or, if possible, by using an alternative drug that would not have a pharmacokinetic effect on the ADHD drug.
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research
Condition:   Attention Deficit Disorder With Hyperactivity Interventions:   Other: NEUROFEEDBACK;   Other: CONTROL Sponsors:   University Hospital, Geneva;   University of Geneva, Switzerland Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The study aimed to investigate if the behaviours suggestive of ADHD were more frequent in a population of children attending the Emergency Department (ED) for injuries, rather than for other causes.
Source: BMC Pediatrics - Category: Pediatrics Authors: Tags: Research article Source Type: research
Abstract Methylphenidate is commonly used for the treatment of attention deficit hyperactivity disorder. The cardiovascular safety of methylphenidate has been a subject of debate with some studies indicating that methylphenidate increases the likelihood of experiencing a myocardial infarction. However, it is unknown whether methylphenidate worsens the extent of injury during an ischemic insult. The purpose of this study was to determine whether short term exposure to methylphenidate increases the extent of myocardial injury during an ischemic insult. Male and female rats received methylphenidate (5 mg/kg/day) or s...
Source: Physiological Research - Category: Physiology Authors: Tags: Physiol Res Source Type: research
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Source: The World Journal of Biological Psychiatry - Category: Psychiatry Authors: Tags: World J Biol Psychiatry Source Type: research
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Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
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Source: Epidemiology and Psychiatric Sciences - Category: Psychiatry Tags: Epidemiol Psychiatr Sci Source Type: research
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