ZO-1 associates with α3 integrin and connexin43 in trabecular meshwork and Schlemm's canal cells.

ZO-1 associates with α3 integrin and connexin43 in trabecular meshwork and Schlemm's canal cells. Int J Physiol Pathophysiol Pharmacol. 2020;12(1):1-10 Authors: Li X, Acott TS, Nagy JI, Kelley MJ Abstract Cellular structures that perform essential homeostatic functions include tight junctions, gap junctions, desmosomes and adherens junctions. The aqueous humor, produced by the ciliary body, passes into the anterior chamber of the eye and is filtered by the trabecular meshwork (TM), a tiny tissue found in the angle of the eye. This tissue, along with Schlemm's canal (SC) inner wall cells, is thought to control intraocular pressure (IOP) homeostasis for normal, optimal vision. The actin cytoskeleton of the tissue plays a regulatory role in maintaining IOP. One of the key risk factors for primary open angle glaucoma is persistent elevation of IOP, which compromises the optic nerve. The ZO-1 (Zonula Occludens-1), extracellular matrix protein integrins, and gap junction protein connexin43 (Cx43) are widely expressed in many different cell populations. Here, we investigated the localization and interactions of ZO-1, α3 integrin, β1 integrin, and Cx43 in cultured porcine TM and SC cells using RT-PCR, western immunoblotting and immunofluorescence labeling with confocal microscopy, along with co-immunoprecipitation. ZO-1 partially co-localized with α3 integrin, but not with β1 integrin, and co-immunoprecipitated with Cx43, as well as wi...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

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Purpose of review The subject of artificial intelligence has recently been responsible for the advancement of many industries including aspects of medicine and many of its subspecialties. Within ophthalmology, artificial intelligence technology has found ways of improving the diagnostic and therapeutic processes in cornea, glaucoma, retina, and cataract surgery. As demands on the modern ophthalmologist grow, artificial intelligence can be utilized to help address increased demands of modern medicine and ophthalmology by adding to the physician's clinical and surgical acumen. The purpose of this review is to highlight the...
Source: Current Opinion in Ophthalmology - Category: Opthalmology Tags: REFRACTIVE SURGERY: Edited by Jimmy K. Lee Source Type: research
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Source: Archivos de la Sociedad Espanola de Oftalmologia - Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research
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Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research
Condition:   Glaucoma Intervention:   Procedure: Express implant device Sponsor:   Menoufia University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: The findings of this study will confirm whether bimatoprost is beneficial to patients with POAG. Systematic review registration: INPLASY202040118.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Conclusions: The results of this study will help to create proposals for the treatment of POAG using NP. Systematic review registration: INPLASY202040107.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
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Source: International Ophthalmology - Category: Opthalmology Source Type: research
Abstract PURPOSE: To determine possible correlations between different levels of blood pressure (BP) control and retinal microvascular changes in the macula and optic nerve head, using coherence tomography angiography (OCTA) in hypertensive patients without hypertensive retinopathy. METHODS: This was an observational, cross-sectional study. Seventy-three patients and 40 healthy volunteers were included in this study. The patients and volunteers were divided into four groups and from each participant one eye was selected randomly: Group A comprised 32 hypertensive patients with intensive BP control; Group B co...
Source: Current Eye Research - Category: Opthalmology Authors: Tags: Curr Eye Res Source Type: research
Condition:   Pseudoexfoliation Glaucoma Interventions:   Procedure: Phacoemulsification;   Device: Selective Laser Trabeculoplasty Sponsors:   Jayme Vianna;   Glaucoma Research Society of Canada;   Canadian Glaucoma Society Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Interview with Mae O. Gordon, PhD, author of Evaluation of a Primary Open-Angle Glaucoma Prediction Model Using Long-term Intraocular Pressure Variability Data: A Secondary Analysis of 2 Randomized Clinical Trials
Source: JAMA Specialty Journals Author Interviews - Category: General Medicine Authors: Source Type: podcasts
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