Neurodevelopmental Outcomes of Prenatal Preeclampsia Exposure.
Neurodevelopmental Outcomes of Prenatal Preeclampsia Exposure. Trends Neurosci. 2020 Apr;43(4):253-268 Authors: Gumusoglu SB, Chilukuri ASS, Santillan DA, Santillan MK, Stevens HE Abstract Preeclampsia is a dangerous hypertensive disorder of pregnancy with known links to negative child health outcomes. Here, we review epidemiological and basic neuroscience work from the past several decades linking prenatal preeclampsia to altered neurodevelopment. This work demonstrates increased rates of neuropsychiatric disorders [e.g., increased autism spectrum disorder, attention deficit hyperactivity disorder (ADHD)] in children of preeclamptic pregnancies, as well as increased rates of cognitive impairments [e.g., decreased intelligence quotient (IQ), academic performance] and neurological disease (e.g., stroke and epilepsy). We also review findings from multiple animal models of preeclampsia. Manipulation of key clinical preeclampsia processes in these models (e.g., placental hypoxia, immune dysfunction, angiogenesis, oxidative stress) causes various disruptions in offspring, including ones in white matter/glia, glucocorticoid receptors, neuroimmune outcomes, cerebrovascular structure, and cognition/behavior. This animal work implicates potentially high-yield targets that may be leveraged in the future for clinical application. PMID: 32209456 [PubMed - in process]
Publication date: Available online 26 May 2020Source: NeuroImage: ClinicalAuthor(s): Naofumi Tomita, Steven Jiang, Matthew E. Maeder, Saeed Hassanpour
Publication date: Available online 26 May 2020Source: NeuroImage: ClinicalAuthor(s): Sheut-Ling Lam, Marion Criaud, Analucia Alegria, Gareth J. Barker, Vincent Giampietro, Katya Rubia
One commonly reported phenomenon in the first months of the Covid-19 era in the United States has been the reduction in emergency department (ED) visits and hospitalizations of patients with heart attacks, strokes and other acute, non-Covid illnesses . Less is known about whether and how the number of patients presenting to EDs for psychiatric problems has changed.
ConclusionEnvironmental exposures, especially acetaminophen ingestion during human preterm pregnancy, can modulate CYP2E1 metabolic activity.
This article explores connections between ASD and SUD and the impact on development, screening and treatment. The article proposes culturally constructed narratives associated with both diagnoses may be responsible for the dearth of research and literature. Constructed narratives of ASD and SUD do not naturally intersect and the resulting disconnect can create a cognitive dissonance that could allow the medical and general community to neglect this life-threatening dual diagnosis. PMID: 32471596 [PubMed - as supplied by publisher]
Publication date: Available online 30 May 2020Source: Brain, Behavior, and ImmunityAuthor(s): Chalystha Yie Qin Lee, Ashley E. Franks, Elisa L. Hill-Yardin
Publication date: Available online 30 May 2020Source: EXPLOREAuthor(s): Lena Sagi-Dain, Shlomi Sagi
Publication date: Available online 30 May 2020Source: European Journal of Integrative MedicineAuthor(s): Jingyi Shao, Lingming Zhou, Tianyu Shao, Minrui Ding, Zhuqing Jin
Publication date: July 2020Source: American Heart Journal, Volume 225Author(s): Yingying Yang, Zhonghe Zhou, Yuesong Pan, Huisheng Chen, Yilong Wang, ARAIS Protocol Steering Group
Authors: Poznyak AV, Zhang D, Grechko AV, Wu WK, Orekhov AN Abstract Atherosclerosis is a major cause of disease-related mortality around the globe. The main characteristic of the disease is an accumulation of plaque on the arterial wall and subsequent erosion or rupture of some plaques. Atherosclerosis often leads to cardiovascular disease and such acute complications as myocardial infarction or ischaemic stroke due to thrombus formation. Most recent advances in atherosclerotic research state that the modifications of low- density lipoprotein (LDL) are one of the most significant stages in the disease initiation, ...