Active mTOR in Lung Epithelium Promotes Epithelial-Mesenchymal Transition and Enhances Lung Fibrosis.

CONCLUSIONS: mTOR activation in lung epithelial cells promoted lung fibrosis and the expression of ANGPTL4, a novel downstream target of the mTOR pathway, which could be related to the etiology of fibrosis.
PMID: 32208980 [PubMed - as supplied by publisher]

Source: American Journal of Respiratory Cell and Molecular Biology - March 24, 2020 Category: Molecular Biology Authors: Saito M, Mitani A, Ishimori T, Miyashita N, Isago H, Mikami Y, Noguchi S, Tarui M, Nagase T Tags: Am J Respir Cell Mol Biol Source Type: research