Resistance to Peloruside A and Laulimalide: Functional Significance of Acquired βI-Tubulin Mutations at Sites Important for Drug-Tubulin Binding.

This study provides the first direct evidence that A296 and R306 of βI-tubulin are important determinants of the PLA and LAU response in cancer cells. PMID: 24245693 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/24245693?dopt=Abstract

Source: Current Cancer Drug Targets - November 12, 2013 Category: Cancer & Oncology Authors: Kanakkanthara A, Eras J, Northcote PT, Cabral F, Miller JH Tags: Curr Cancer Drug Targets Source Type: research