Molecules, Vol. 25, Pages 1525: Anti-Estrogenic Activity of Guajadial Fraction, from Guava Leaves (Psidium guajava L.)

Molecules, Vol. 25, Pages 1525: Anti-Estrogenic Activity of Guajadial Fraction, from Guava Leaves (Psidium guajava L.) Molecules doi: 10.3390/molecules25071525 Authors: Jaqueline Moraes Bazioli Jonas Henrique Costa Larissa Shiozawa Ana Lúcia Tasca Gois Ruiz Mary Ann Foglio João Ernesto de Carvalho The research of natural products has allowed for the discovery of biologically relevant compounds inspired by plant secondary metabolites, which contributes to the development of many chemotherapeutic drugs used in cancer treatment. Psidium guajava leaves present a diverse phytochemical composition including flavonoids, phenolics, meroterpenoids, and triterpenes as the major bioactive constituents. Guajadial, a caryophyllene-based meroterpenoid, has been studied for potential anticancer effects tested in tumor cells and animal experimental models. Moreover, guajadial has been reported to have a mechanism of action similar to tamoxifen, suggesting this compound as a promisor phytoestrogen-based therapeutic agent. Herein, the anti-estrogenic action and anti-proliferative activity of guajadial is reported. The enriched guajadial fraction was obtained by sequential chromatographic techniques from the crude P. guajava dichloromethane extract showing promising anti-proliferative activity in vitro with selectivity for human breast cancer cell lines MCF-7 and MCF-7 BUS (Total Growth Inhibition = 5.59 and 2.27 µg·mL−1, respective...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research