Deficiency in the anti-apoptotic protein DJ-1 promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via p53 [Gene Regulation]

In conclusion, reduced DJ-1 expression promotes inflammation and IEC apoptosis via p53 in colitis, suggesting that the modulation of DJ-1 expression may be a potential therapeutic strategy for managing colitis.

Source: Journal of Biological Chemistry - March 26, 2020 Category: Chemistry Authors: Jie Zhang, Min Xu, Weihua Zhou, Dejian Li, Hong Zhang, Yi Chen, Longgui Ning, Yuwei Zhang, Sha Li, Mengli Yu, Yishu Chen, Hang Zeng, Li Cen, Tianyu Zhou, Xinxin Zhou, Chao Lu, Chaohui Yu, Youming Li, Jing Sun, Xiaoni Kong, Zhe Shen Tags: Molecular Bases of Disease Source Type: research