Deficiency in the anti-apoptotic protein DJ-1 promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via p53 Gene Regulation

In conclusion, reduced DJ-1 expression promotes inflammation and IEC apoptosis via p53 in colitis, suggesting that the modulation of DJ-1 expression may be a potential therapeutic strategy for managing colitis.
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Molecular Bases of Disease Source Type: research

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Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Kehinde S. Olaniyi, Oluwatobi A. Amusa
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: September 2020Source: Neurochemistry International, Volume 138Author(s): Cui Liu, Yan Xue, Mei-Fang Liu, Ying Wang, Lei Chen
Source: Neurochemistry International - Category: Neuroscience Source Type: research
Authors: Wang S, Guo P, Feng M, Qian M, Shen X, Wang G PMID: 32447268 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Condition:   Periodontal Diseases Intervention:   Drug: Sodium hypochlorite gel application Sponsor:   University of Messina Completed
Source: - Category: Research Source Type: clinical trials
;llertz A Abstract The release and absorption profile of an oral medication is influenced by the physicochemical properties of the drug and its formulation, as well as by the anatomy and physiology of the gastrointestinal (GI) tract. During drug development the bioavailability of a new drug is typically assessed in early clinical studies in a healthy adult population. However, many disease conditions are associated with an alteration of the anatomy and/or physiology of the GI tract. The same holds true for some subpopulations, such as paediatric or elderly patients, or populations with different ethnicity. The var...
Source: European Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharm Sci Source Type: research
Gulcin Tezcan1, Ekaterina V. Martynova1, Zarema E. Gilazieva1, Alan McIntyre2, Albert A. Rizvanov1 and Svetlana F. Khaiboullina1,3* 1Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia 2Centre for Cancer Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, United Kingdom 3Department of Microbiology and Immunology, University of Nevada, Reno, Reno, NV, United States Inflammation has a crucial role in protection against various pathogens. The inflammasome is an intracellular multiprotein signaling complex that is linked to pathogen sensing and...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Biomedical researchers at Cedars-Sinai Medical Center in Los Angeles, CA have caught the attention of National Geographic. The magazine published a special edition this month covering "The Future of Medicine" that highlights the innovative stem-cell science of Cedars-Sinai, showing how investigators there are seeking to use stem cells and organs-on-chips to tailor personalized medical treatments. The cover photo of the special issue features research being conducted at Cedars-Sinai in collaboration with Boston, MA-based Emulate, a startup developing a tissue-based technology designed to replicate human organ-leve...
Source: MDDI - Category: Medical Devices Authors: Tags: R & D Source Type: news
We read with interest the paper by Camacho-Soto et al., based on Medicare data [1]. In their case-control study of Parkinson's disease (PD) risk, they observed an inverse association between PD and inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). They also reported that PD was inversely associated with IBD-associated conditions and with IBD-associated surgical procedures and immunosuppressant use, even among Medicare beneficiaries without IBD. They found IBD to be associated with a lower risk of developing PD in the adjusted model for a population aged> 65 years (OR 0.86, 95%...
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Correspondence Source Type: research
(American Associates, Ben-Gurion University of the Negev) The new study, published in The European Journal of Internal Medicine, found cannabis therapy is safe and efficacious for elderly patients who are seeking to address cancer symptoms, Parkinson's disease, post-traumatic stress disorder, ulcerative colitis, Crohn's disease, multiple sclerosis, and other medical issues. After six months, more than 18 percent of patients surveyed had stopped using opioid analgesics or had reduced their dosage.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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Source: British Journal of Dermatology - Category: Dermatology Authors: Tags: Letter to the Editor Source Type: research
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