Prevalence and clinical correlates of self-injurious behavior in Tourette syndrome - Stafford M, Cavanna AE.

Tourette syndrome (TS) is a neurodevelopmental condition characterized by the presence of multiple tics. In addition to common behavioral co-morbidities such as obsessive-compulsive disorder and attention-deficit and hyperactivity disorder, patients with T...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

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Gilles de la Tourette syndrome (TS) is a neuropsychiatric neurodevelopmental disorder with the cardinal clinical features of motor and phonic tics. Clinical phenomenology can be complex since, besides tics, there are other features including premonitory urges preceding tics, pali-, echo-, and coprophenomena, hypersensitivity to external stimuli, and symptom dependency on stress, attention, and other less well-defined factors. Also, the rate of comorbidities, particularly attention deficit hyperactivity disorder and obsessive-compulsive disorder, is high. Mirroring the complexities of the clinical course and phenomenology, ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Tics are the hallmark feature of Tourette syndrome (TS), but psychiatric and sensory symptoms are widely prevalent and increasingly recognized as core manifestations of the disorder. Accumulating evidence suggests that these psychiatric and sensory symptoms exert greater influence on quality of life (QOL) than tics themselves. However, much remains uncertain about determinants of QOL in TS due to the complexity of the clinical presentation. Here, we sought to clarify the association between health-related QOL (HRQOL) and common psychiatric and sensory symptoms in adults with TS and other chronic tic disorders. To do so, we...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
In this study, we aimed to investigate whether the serotonin transporter (SERT) gene (SLC6A4) was differentially expressed among GTS individuals compared to healthy controls, and whether DNA variants (the SERT-linked polymorphic region 5-HTTLPR, together with the associated rs25531 and rs25532 variants, and the rare Ile425Val variant) or promoter methylation of SLC6A4 were associated with gene expression levels or with the presence of OCD as comorbidity. We observed that SLC6A4 expression is upregulated in GTS individuals compared to controls. Although no specific genotype, allele or haplotype was overrepresented in GTS in...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Tourette syndrome (TS) and Chronic motor/vocal Tic Disorder (CTD) are neurodevelopmental conditions defined by the occurrence of multiple tics. Besides the well-known association with attention deficit/hyperactivity disorder (ADHD) and obsessive-compulsive...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Tic disorders (TD) are a group neuropsychiatric disorders with childhood onset characterized by tics, i.e. repetitive, sudden, and involuntary movements or vocalizations; and Tourette syndrome (TS) is the most severe form of TD. Their clinical manifestations are diverse; and are often associated with various psychopathological and/or behavioral comorbidities, including attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety, depression, and sleep disorders. Individual severity and response to treatment are highly variable, and there are some refractory cases, which are less responsive ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Tourette syndrome (TS), also known as Tourette ’s disorder, is a neurodevelopmental disorder with onset in early childhood characterized by multiple motor tics and at least one vocal tic that have been present for longer than 1 year. TS is a model neuropsychiatric disorder, in that the vast majority of affected individuals, whether ascertained in clinical or community settings, experience at least one co-occurring psychiatric disorder, such as attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, and/or mood, anxiety, and specific learning disorders (1).
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
Conclusions: Since the presence of behavioural comorbidities influences individualised treatment approaches, it is likely that a more precise characterisation of TS phenotypes, including cognitive aspects, will result in improved levels of care for patients with tic disorders. PMID: 32372718 [PubMed - as supplied by publisher]
Source: Cognitive Neuropsychiatry - Category: Psychiatry Tags: Cogn Neuropsychiatry Source Type: research
ConclusionsThe use of pharmacotherapy options for tic management observed at a specialist clinic for adults with TS reflects guideline recommendations. We found that the presence of co-morbid obsessive-compulsive disorder/behaviours correlates with the choice of anti-dopaminergic medications over alpha-2-agonists, in line with available evidence on the efficacy of anti-dopaminergic medications for the treatment of specific tic –related behavioural symptoms.
Source: Neurological Sciences - Category: Neurology Source Type: research
IntroductionAlthough defined by the presence of tics, most patients with Gilles de la Tourette syndrome (TS) also suffer from different psychiatric disorders. While much is known about clinical characteristics of comorbidities such as attention deficit/hyperactivity disorder (ADHD), obsessive compulsive disorder (OCD), depression, and anxiety disorders, only very little is known about rage attacks. Most of this data is based on small studies in children. Until today no larger studies have been performed in adults with TS—most likely because of the lack of validated instruments. The aim of this study was to develop a ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Becker muscular dystrophy (BMD) results in a decrease of dystrophin with potential implications for cognitive and psychiatric complications. To better understand these concerns, we conducted a retrospective study of the neuropsychological symptoms and respective pharmacotherapies of 74 BMD patients. Eight (10.8%) patients exhibited autistic features, 26 (35.1%) exhibited inattention/hyperactivity, 23 (31.1%) had learning difficulties, 27 (36.5%) had language delays, 9 (12.2%) had global intellectual delays, 4 (5.4%) had features of tics or Tourette's, 27 (36.5%) had emotion dysregulation, 14 (18.9%) had obsessive-compulsiv...
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
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