A pilot study: effect of erythrocyte lifespan determined by a modified carbon monoxide breath test on glycosylated hemoglobin interpretation
In this study, we recruited 120 patients with diabetes
mellitus and 85 nondiabetic controls. The HbA1c and the RBC lifespan were detected by
high-performance liquid chromatography and the advanced carbon monoxide breath detection method,
respectively. Potential correlations of gender and age with HbA1c were analyzed and a receiver
operator characteristic curve was generated to get the HbA1c cut-off for every RBC lifespan group.
It was confirmed that HbA1c has no correlation with gender or age. The correlation formula between
the HbA1c diagnostic criteria and RBC lifespan was derived to correct the HbA1c diagnostic criteria
using the least-square method. The RBC-lifespan-corrected HbA1c diagnostic criteria provided 100%
sensitivity and specificity fo...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Hong-Wei Chu, Yong-Jian Ma and Zhen-He Huang Source Type: research
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