Skin Infections Caused by Emerging Candida Species

AbstractPurpose of ReviewSkin infections caused by yeasts are becoming more frequent, mainly the ones associated withCandida albicans. However, the non-albicansCandida species are emerging with new species that have lower susceptibility and greater resistance to antifungal agents. Therefore, the objective of this review is to learn about the newCandida emerging species that are causing skin infections, their diagnosis, and treatment.Recent FindingsNew emerging species that cause skin disease have been found such asC. duobushaemulonii,C. africana, andC. auris, the latter being a health problem due to its difficult identification and high resistance to azoles, echinocandins, and polyenes; consequently, new alternatives for its diagnosis and treatment have been sought.SummaryOf the 200Candida species known, approximately 30 are causing infection in humans. Some of these species are part of the skin microbiome, but they can become pathogenic and cause infection. Several of these emerging species have shown higher resistance to conventional antifungal medications, so it is important to know these new species, its epidemiology, risk factors, diagnosis, and treatment.
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research

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Invasive fungal infections caused by Candida species affect approximately 700,000 people worldwide resulting in 300,000 deaths annually. Besides Candida albicans, other members of the genus have gained relevance in the last two decades, including C. parapsilosis whose incidence is particularly high amongst low birth weight neonates. To investigate the virulence properties of this pathogen several techniques have been developed for generating knock-out mutants, however, no target locus for knock-in approaches have been published so far. Here we report CpNEUT5L (N5L), an intergenic locus in C. parapsilosis, and introduce an ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In this study, we screened a library of 1068 FDA-approved drugs to identify hits that exhibit broad-spectrum antifungal activity. Robenidine, an anticoccidial agent which has been widely used to treat coccidian infections of poultry and rabbits, was identified in this screen. Physiological concentration of robenidine (8 μM) was able to significantly inhibit yeast cell growth, filamentation and biofilm formation of Candida albicans – the most extensively studied human fungal pathogen. Moreover, we observed a broad-spectrum antifungal activity of this compound against fluconazole resistant clinical isolates of C. al...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
CONCLUSIONS: CCC must be considered in full-term newborns with maculopapular rash at birth or during the first days of life. The absence of alternative sources for bloodstream infection in the present case suggests a potential etiopathogenic relationship between CCC and maternal candidemia. It is reasonable to rule out postpartum candidemia when CCC is suspected. PMID: 32493666 [PubMed - as supplied by publisher]
Source: Revista Iberoamericana de Micologia - Category: Biology Authors: Tags: Rev Iberoam Micol Source Type: research
Small molecule inhibitors targeting sterol 14α-demethylase (CYP51): synthesis, molecular modelling and evaluation against Candida albicans. ChemMedChem. 2020 May 27;: Authors: Simons C, Binjubair F, Warrilow AG, Puri K, Braidley PJ, Tatar E, Kelly SL, Kelly DE, Parker J Abstract Fungal infections are a global issue affecting over 150 million people worldwide annually with 750,000 of these caused by invasive Candida infections. Azole drugs are the frontline treatment against fungal infections however resistance to current azole antifungals in C. albicans poses a threat to public health. Two serie...
Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research
In this study, a green approach was developed to control the pathogenic Candida spp. isolated from clinical samples, and prior data collections, ethics approval was obtained. Sixty candida isolates were obtained from the different device-associated infections and identified as Candida albicans, Candida tropicalis, Candida krusei, Candida parapsilosis, and Candida glabrata with prevalence rates 41.6, 38.3, 8.3, 6.6, and 5%, respectively. On the other hand, silver nanoparticles (Ag-NPs) were extra-cellular synthesized by biomass filtrate of previously identified Penicillium chrysogenum strain F9. The physico-chemical charact...
Source: Biological Trace Element Research - Category: Biology Authors: Tags: Biol Trace Elem Res Source Type: research
M, Neves RP Abstract The Candida parapsilosis complex has been associated with highly refractory infections mainly due to the presence of biofilms. High glucose levels enable the development of this virulence factor which can aggravate the clinical condition of patients with diabetes mellitus, those using parenteral nutrition, with invasive medical device, including others. Combined antifungal therapy, such as azole and cyclooxygenase inhibitors, may be an alternative in such infections since they modulate prostaglandin production favoring the adhesion and development of biofilms. Thus, the present study aimed to ...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Tags: Infect Genet Evol Source Type: research
Authors: Alves NCPOP, Moreira TA, Malvino LDS, Rodrigues JJ, Ranza R, de Araújo LB, Pedroso RDS Abstract Psoriasis and psoriatic arthritis are chronic, relapsing, immune-based diseases. Psoriatic patients may have nail involvement in 50 to 80% of cases, and this may reach 85% in patients with joint disease, in spite of the fact that the relationship between psoriasis and onychomycosis is not well established. The aim of this study was to investigate the occurrence of onychomycosis in patients with nail disorders and diagnosis of psoriasis and psoriatic arthritis. This was a cross-sectional study in which 38 ...
Source: Dermatology Research and Practice - Category: Dermatology Tags: Dermatol Res Pract Source Type: research
Abstract Curcumin is one of the important natural compounds that is extracted from turmeric. This compound and its derivatives have numerous biological properties, including antioxidant, anticancer, anti-inflammatory, antimicrobial and healing effects. Extensive research in various fields has been conducted on turmeric as it is widely used as a food additive. The significant antifungal activity is one of the major effects of curcumin. In this paper, recent studies on the effects of different forms of curcumin drug on the candidiasis were systematically examined and discussed. The data in this study were extracted ...
Source: Current Drug Discovery Technologies - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Discov Technol Source Type: research
AbstractPurpose of ReviewThe management of fungal infections is challenging, especially given the continued increase in fluconazole resistance and prevalence of non-albicansCandida spp. Urinary tract infections due to non-albicans and fluconazole-resistantCandida are particularly problematic given the uncertainty in determining true infection from colonization and the limited number of antifungal agents with adequate penetration to the site of infection. While our understanding of mechanisms of resistance and pharmacokinetics and pharmacodynamics continues to improve, it is combatted by the emergence of novel, difficult-to...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
Abstract Traditional herbal monomers (THMs) are widely distributed in many traditional Chinese formulas (TCFs) and decoctions (TCDs) and are frequently used for the prevention and treatment of fungal infections. The antifungal activities of five common THMs, including sodium houttuyfonate (SH), berberine (BER), palmatine (PAL), jatrorrhizine (JAT) and cinnamaldehyde (CIN), and their potential for inducing cell wall remodeling (CWR), were evaluated against Candida albicans SC5314 and Candida auris 12372. SH/CIN plus BER/PAL/JAT showed synergistic antifungal activity against both Candida isolates. Furthermore, SH-as...
Source: Biofouling - Category: Molecular Biology Authors: Tags: Biofouling Source Type: research
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