Daily Aspirin Won't Stop Dementia, Study Finds

Title: Daily Aspirin Won't Stop Dementia, Study FindsCategory: Health NewsCreated: 3/25/2020 12:00:00 AMLast Editorial Review: 3/26/2020 12:00:00 AM
Source: MedicineNet Alzheimer - Category: Geriatrics Source Type: news

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Evidence strongly suggests that the global faltering of mitochondrial function throughout the body with advancing age has a lot to do with a decline in the effectiveness of mitophagy. Mitochondria are the power plants of the cell, a herd of hundreds swarming and replicating like bacteria in every cell to produce the chemical energy store molecule ATP. Mitophagy is the specialized form of autophagy that destroys worn and damaged mitochondria, recycling their component parts. Without it, cells would become overtaken by broken, malfunctioning mitochondria. Mitochondrial dysfunction leads to too little ATP, but also higher lev...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
ConclusionWe provide a real-world insight into the heterogeneous management and treatment pathways of newly diagnosed dementia patients and a subset of Alzheimer ’s Disease patients from across Europe.
Source: Social Psychiatry and Psychiatric Epidemiology - Category: Psychiatry Source Type: research
ConclusionDespite the lack of statistical significance, when assessing the efficacy and safety outcomes for each drug in the evidence network, donepezil appeared to have a more favourable overall benefit/risk profile for patients with DLB. Further comparative trials are required to improve understanding of the true difference between existing and potential future treatment options.
Source: Neurology and Therapy - Category: Neurology Source Type: research
One possible expansion of present immunotherapies for Alzheimer's disease is to more specifically track and target oligomeric forms of amyloid-β. Efforts to reduce amyloid-β in the brain have, after many years of failure, started to succeed in that goal in human trials, but patients are not exhibiting benefits as a result. It remains to be seen whether or not this is because amyloid-β is a trigger for other self-sustaining pathological mechanisms, such as cellular senescence of supporting cells in the brain, and thus removing it does little good once Alzheimer's is underway. An alternative view is that perha...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
AbstractBackgroundSeizures are an important comorbidity in Alzheimer ’s disease (AD). Conflicting results regarding clinical parameters associated with seizures in AD were previously reported. Data on seizure recurrence risk, a crucial parameter for treatment decisions, are lacking.MethodsNational Alzheimer ’s Coordinating Center data were analyzed. Seizure prevalence in AD and an association with disease duration were investigated. Associations of seizures with age of AD onset and with cognitive and functional performance, and seizure recurrence risk were studied.Results20,745 individuals were investigated. In...
Source: Journal of Neurology - Category: Neurology Source Type: research
Background: Semantic dementia (SD) is characterized by progressive semantic anomia extending to a multimodal loss of semantic knowledge. Although often considered an early-onset dementia, SD also occurs in later life, when it may be misdiagnosed as Alzheimer disease (AD). Objective: To evaluate late-onset SD in comparison to early-onset SD and to AD. Methods: We identified 74 individuals with SD and then compared those with late-onset SD (≥65 years of age) to those with early-onset SD (
Source: Cognitive and Behavioral Neurology - Category: Neurology Tags: Original Studies Source Type: research
Abstract Lumateperone (ITI-007) is a tosylate salt with binding affinities to receptors implicated in the therapeutic actions of antipsychotic medications, including the serotonin 5HT2A receptors, dopamine D2 and D1 receptors and the serotonin transporter. It has a unique mechanism of action because it simultaneously modulates serotonin, dopamine, and glutamate neurotransmission, implicated in serious mental illness. It can be considered a multi-target-directed ligand and a multifunctional modulator of serotoninergic system with possible precognitive, antipsychotic, antidepressant and anxiolytic properties. Lumate...
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Tags: CNS Neurol Disord Drug Targets Source Type: research
Percutaneous endoscopic gastrostomy (PEG) tube placement has not demonstrated to have mortality or quality of life benefits in patients with dementia. Still it is used in patients for nutritional support and practice patterns have been variable throughout the country. To report the trend of PEG placement in patients with Alzheimer ’s disease on a national scale and associated healthcare utilization, we analyzed largest available national database.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Poster abstracts Source Type: research
DEMENTIA symptoms can be difficult to spot in its early stages, although there are a number of warning signs to look out for - including memory loss. These are the five most common early symptoms of Alzheimer's disease. Should you speak to a doctor about your dementia risk?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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