4 β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters

In conclusion, PXR activation-elevated 4βHC is a signaling molecule that represses cholesterol influx and induces efflux. The PXR-4βHC-LXR pathway could link the hepatic xenobiotic exposure and the regulation of cholesterol transport in peripheral tissues.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research