Our evolving understanding of the pathogenesis and presentations of chronic rhinosinusitis

Until recently, chronic rhinosinusitis (CRS) was viewed as a chronic infectious disease of the sinuses caused by anaerobic bacteria. This dogma led to the concept that, as with any abscess in a closed space, the primary modalities of treatment should be surgical drainage and antibiotics. Not surprisingly, few patients responded favorably. Recent years have seen a revolution in our thinking, with the recognition that CRS is a chronic inflammatory disease —a syndrome comprising numerous chronic inflammatory diseases.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Editorial Source Type: research