A Study to Assess AK002 in Eosinophilic Gastritis and/or Eosinophilic Duodenitis (Formerly Referred to as Eosinophilic Gastroenteritis)

Conditions:   Eosinophilic Gastritis;   Eosinophilic Duodenitis Interventions:   Drug: antolimab (AK002);   Other: Placebo Sponsor:   Allakos, Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Conditions:   Eosinophilic Gastritis;   Eosinophilic Duodenitis Interventions:   Drug: antolimab (AK002);   Other: Placebo Sponsor:   Allakos, Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Carvalho A, Lu J, Francis JD, Moore RE, Haley KP, Doster RS, Townsend SD, Johnson JG, Damo SM, Gaddy JA Abstract Calgranulin proteins are an important class of molecules involved in innate immunity. These members of the S100 class of the EF-hand family of calcium-binding proteins have numerous cellular and antimicrobial functions. One protein in particular, S100A12 (also called EN-RAGE or calgranulin C), is highly abundant in neutrophils during acute inflammation and has been implicated in immune regulation. Structure-function analyses reveal that S100A12 has the capacity to bind calcium, zinc, and copper,...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Publication date: Available online 12 February 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Amelia Licari, Martina Votto, Luigia Scudeller, Annalisa De Silvestri, Chiara Rebuffi, Antonella Cianferoni, Gian Luigi MarsegliaAbstractBackgroundPrimary eosinophilic gastrointestinal diseases (EGIDs) are increasingly described disorders that include eosinophilic esophagitis (EoE), eosinophilic gastritis (EoG), gastroenteritis (EoGE) and colitis (EoC). The exact epidemiology of non-EoE EGIDs is still unclear.ObjectiveTo evaluate the epidemiology of non-esophageal EGIDs (non-EoE EGIDs) in adults ...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Eosinophilic GI disorders (EGIDs) are caused by the accumulation and activation of eosinophils and mast cells. AK002 (anti-siglec-8 antibody) depletes eosinophils and inhibits mast cell activity, potentially addressing the underlying pathophysiology of EGIDs. AK002 reported statistically significant reductions in eosinophil counts and improvements in eosinophilic gastritis/gastroenteritis (EG/EGE) symptoms in a prospective Phase 2 randomized controlled trial (RCT) study in patients with EG/EGE. Here we report the efficacy of AK002 in the subgroup of patients with concomitant eosinophilic esophagitis (EoE).
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
To better understand the real-world diagnostic journey of patients with eosinophilic gastritis and/or eosinophilic gastroenteritis (EG/EGE).
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
This study highlights that the diversity of the Helicobacteraceae family remains to be fully explored.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion: CVS is not rare in adults, but its diagnosis is usually delayed due to poor recognition of the condition. Clinician awareness of CVS should be enhanced to improve early diagnosis. Core tip: Cyclic vomiting syndrome has a tremendous impact on the quality of life, but it is poorly recognized and is always misdiagnosed leading to a diagnostic delay of several years, especially in adults. The article presented a case report of cyclic vomiting syndrome of adult; we hope the article will attribute to increased awareness of physician and reduce delayed diagnosis.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
While great strides have been made in diagnosing eosinophilic esophagitis (EoE) over the past decade, the journey to diagnosis of eosinophilic gastrointestinal disorders (EGIDs) below the esophagus remains arduous. EGIDs are named after the location of the gastrointestinal tract that is infiltrated by eosinophils. These include eosinophilic gastritis, enteritis, gastroenteritis and colitis. While the prevalence of EGIDs is currently reported to be around 2-5/100,000, it is possible that it is underestimated given the difficulties many EGID patients face before establishing their diagnosis.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Perspective Source Type: research
Although great strides have been made in diagnosing eosinophilic esophagitis (EoE) over the past decade, the journey to diagnosis of eosinophilic gastrointestinal disorders (EGIDs) below the esophagus remains arduous. Eosinophilic gastrointestinal disorders are named after the location of the gastrointestinal tract that is infiltrated by eosinophils. These include eosinophilic gastritis, enteritis, gastroenteritis, and colitis. Although the prevalence of EGIDs is currently reported to be approximately 2 to 5/100,000, possibly it is underestimated given the difficulties many EGID patients face before establishing their diagnosis.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Perspective Source Type: research
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