Rituximab Treatment for Psychosis and/or Obsessive Compulsive Disorder With Probable Immune System Involvement

Conditions:   Obsessive-Compulsive Disorder;   Obsessive-Compulsive Behavior;   Schizophrenia;   Delusional Disorder;   Brief Psychotic Disorder;   Schizo Affective Disorder;   Other Psychoses;   Unspecified Psychosis Intervention:   Drug: Rituximab Sponsors:   Uppsala University Hospital;   Uppsala University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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The advent and application of high-throughput sequencing is revolutionizing our understanding of the molecular neurobiology of diverse psychiatric disorders. Whole-genome sequencing, which targets the coding regions of the genome, and whole-exome sequencing are being applied to study multiple psychiatric disorders, including autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder, schizophrenia, and Tourette ’s disorder, among others [(1–3); https://schema.broadinstitute.org]. These studies have demonstrated a role for ultrarare, deleterious, frequently de novo variation in each disorder, and h...
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
Clozapine is thought to induce obsessive compulsive symptoms (OCS) in schizophrenic patients. However, because OCS are often comorbid with schizophrenia regardless of clozapine treatment, it remains unclear wh...
Source: Molecular Brain - Category: Neuroscience Authors: Tags: Micro report Source Type: research
CONCLUSIONS: Trials of antidepressants may be driven mainly by commercial interests, focusing on prevalent diseases and everyday problems. No one can live a full life without experiencing several of the problems for which these drugs were tested. Antidepressants, sometimes called happy pills, could be seen as the modern version of Aldous Huxley's soma pill intended to keep everyone happy in the "Brave New World". PMID: 32444565 [PubMed - as supplied by publisher]
Source: International Journal of Risk and Safety in Medicine - Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research
(CNN) — Weekly sessions of yoga may ease depressive symptoms in people with other mental health issues, according to a systematic review and meta-analysis of existing research. “This is a great result to now encourage people who might be thinking about trying yoga that there’s some scientific evidence that it can be effective for helping reduce depressive symptoms,” said exercise physiologist and study author Jacinta Brinsley, a doctoral candidate at the University of South Australia. Depression is often associated with other mental health conditions. For example, 20 to 40% of people diagnosed with ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Syndicated CBSN Boston CNN Yoga Source Type: news
DISSOCIABLE SOURCE-MONITORING IMPAIRMENTS IN OBSESSIVE-COMPULSIVE DISORDER AND SCHIZOPHRENIA. Eur Psychiatry. 2020 May 14;:1-22 Authors: Lavallé L, Bation R, Dondé C, Mondino M, Brunelin J PMID: 32406366 [PubMed - as supplied by publisher]
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
CONCLUSIONS: The diagnosis of psychological aspects in chronic pruritus is complex. The main diagnostic tool is the thorough taking of the patient history, including psychological aspects. It can be supplemented by standardized questionnaires, but these can not be substitutes. PMID: 32347353 [PubMed - as supplied by publisher]
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
BackgroundAll current approved antipsychotic drugs against schizophrenia spectrum disorders share affinity for the dopamine receptor (D2R). However, up to one-third of these patients respond insufficiently, and in some cases, side-effects outweigh symptom reduction. Previous data have suggested that a subgroup of antipsychotic-naïve patients will respond to serotonin 2A receptor (2AR) blockade.AimsThis investigator-initiated, translational, proof-of-concept study has overall two aims; 1) To test the clinical effectiveness of monotherapy with the newly approved drug against Parkinson's disease psychosis, pimavanserin, ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
We examined grey matter volume (GMV) and white matter integrity (WMI, including fractional anisotropy, mean diffusivity, axial diffusivity and radial diffusivity) in 26 individuals with high SOT, 30 individuals with high SCT, 25 individuals with OCS and 30 individuals with low trait scores (LT) in this study. Correlation analysis between GMV, WMI, Schizotypal Personality Questionnaire (SPQ) scores and Obsessive-Compulsive Inventory-Revised (OCI-R) scores in the subclinical groups was also carried out. We found that the SOT group exhibited increased GMV at the right superior occipital gyrus and the left postcentral gyrus co...
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Conditions:   Obsessive-Compulsive Disorder;   Obsessive-Compulsive Behavior;   Schizophrenia;   Delusional Disorder;   Brief Psychotic Disorder;   Schizo Affective Disorder;   Other Psychoses;   Unspecified Psychosis Intervention:   Drug: Rituximab Sponsors:   Uppsala University Hospital;   Uppsala University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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