Rituximab Treatment for Psychosis and/or Obsessive Compulsive Disorder With Probable Immune System Involvement

Conditions:   Obsessive-Compulsive Disorder;   Obsessive-Compulsive Behavior;   Schizophrenia;   Delusional Disorder;   Brief Psychotic Disorder;   Schizo Affective Disorder;   Other Psychoses;   Unspecified Psychosis Intervention:   Drug: Rituximab Sponsors:   Uppsala University Hospital;   Uppsala University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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mas N PMID: 33028077 [PubMed - as supplied by publisher]
Source: The Australian and New Zealand Journal of Psychiatry - Category: Psychiatry Authors: Tags: Aust N Z J Psychiatry Source Type: research
;re P Abstract Nearly 100 years after the discovery of serotonin, its role remains elusive. The Special Issue Serotonin Research: crossing scales and boundaries presented here in Neuropharmacology covers the diversity and complexity of the serotonin system with its many receptor subtypes. This collection is made up of a selection of nine review articles and 16 research articles. Modulation of serotonin transmission is considered in numerous central nervous system (CNS) diseases including depression, anxiety, schizophrenia, obsessive-compulsive disorders, addiction, Parkinson's disease, and Alzheimer's disease. The...
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Neuropharmacology Source Type: research
In this study, we tested multiple alternative structural models of psychopathology at the genomic level, using the genetic correlations among fourteen psychiatric disorders and related psychological traits estimated from GWAS summary statistics. The best-fitting model included four correlated higher-order factors - externalizing, internalizing, thought problems, and neurodevelopmental disorders - which showed distinct patterns of genetic correlations with external validity variables and accounted for substantial genetic variance in their constituent disorders. A bifactor model including a general factor of psychopathology ...
Source: World Psychiatry - Category: Psychiatry Authors: Tags: World Psychiatry Source Type: research
CONCLUSIONS: Treatment with clozapine leads to improvement in core symptoms of schizophrenia and is also associated with significant improvement in the quality of life, functioning, and disability. PMID: 32915089 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
AbstractEmergency psychiatry has the main role of resolving suicidal behavior and aggression. These severe psychiatric symptoms can be found in many psychiatric disorders such as schizophrenia, bipolar disorder, major depression, personality disorders, cognitive disorders, intellectual disability and substance abuse. Although indications for the use of antipsychotics are limited to a specific group of diseases, they are frequently used as rescue medication in high-risk or nonresponsive cases. Clozapine, the gold standard for TRS (treatment resistant schizophrenia) is effective in controlling aggression. The aim of the rese...
Source: Psychiatric Quarterly - Category: Psychiatry Source Type: research
AbstractPurpose of reviewRepetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulation approach to psychiatric treatment that is FDA approved for the management of major depressive disorder (MDD) and obsessive compulsive disorder (OCD). Standard TMS appears to exert biological effects by inducing current in the cortex more shallowly than deep TMS (dTMS); it may be that this modality of treatment differs from standard TMS. Given the potential difference in the manner in which dTMS stimulates the targeted brain regions, it is reasonable to review and summarize the various off-label and experimental app...
Source: Current Treatment Options in Psychiatry - Category: Psychiatry Source Type: research
In conclusion, multiple dystonia-associated genes interact and contribute to pathogenesis likely through dysregulation of synaptic signalling in striatal medium spiny neurons, adult nigral dopaminergic neurons and frontal cortical neurons. Furthermore, the enrichment of the heritability of psychiatric disorders in the co-expression modules enriched for dystonia-associated genes indicates that psychiatric symptoms associated with dystonia are likely to be intrinsic to its pathophysiology.
Source: Brain - Category: Neurology Source Type: research
Authors: Vani P, Nadella RK, Viswanath B, Jain S PMID: 32795956 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Conclusions: This understanding can open up the need for a gut related approach in these disorders as well as unlock the door for the role of gut related microbiota management. Key Messages:Challenges of managing mental health conditions remain in spite of new pharmacological therapy.Gut dysbiosis is seen in various mental health conditions.Various psychotropic medications can have an influence on the gut microbiota by their antimicrobial effect. PMID: 32772900 [PubMed - as supplied by publisher]
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
Authors: Miniksar DY, Özdemir M Abstract BACKGROUND: Although the effect of obsessive-compulsive disorder (OCD) on sleep is not well-known, recent studies suggest an association between OCD and sleep quality. AIMS: We aimed to assess sleep quality in children and adolescents with OCD and to seek its association with OCD symptoms and OCD severity. METHODS: All of the subjects were assessed using DSM 5 and affective disorders and schizophrenia for school-age children - present and lifetime version, which is based on DSM-IV. The Yale-Brown obsessive-compulsive scale and children's Yale-Brown obsessive-com...
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
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