Exosome miR ‐27a‐3p secreted from adipocytes targets ICOS to promote antitumor immunity in lung adenocarcinoma
ConclusionsAdipocyte ‐derived exo‐miR‐27a‐3p can inhibit ICOS+ T cell proliferation and IFN ‐gamma secretion. The upregulation of ICOS+ T cell functions caused by the downregulation of miR ‐27a‐3p in adipose tissue derived exosomes is one of the potential mechanisms for the improved efficacy of immunotherapy in obese LUAD patients.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Xuehan Fan,
Jingya Wang,
Tingting Qin,
Yujia Zhang,
Wenting Liu,
Kaiting Jiang,
Dingzhi Huang Tags: ORIGINAL ARTICLE Source Type: research
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