Whole brain radiation therapy plus focal boost may be a suitable strategy for brain metastases in SCLC patients: a multi-center study

The treatment for brain metastases in small cell lung cancer (SCLC) is still controversial. The purpose of this study was to compare different brain radiotherapy treatments on SCLC patients with brain metastases.
Source: Radiation Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research

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CONCLUSIONS: MRI surveillance with multiple rounds of SRS may serve a reasonable alternative to PCI or therapeutic WBRT in SCLC. PMID: 31927801 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
This study evaluated an association between whole brain volume loss and neurocognitive decline following prophylactic cranial irradiation (PCI) for limited-stage small-cell lung cancer (SCLC).MethodsThis was a secondary analysis of a prospective clinical trial that accrued patients at a single institution from 2013 to 2016. Patients with limited-stage SCLC treated with standard chemo-radiation received PCI 25  Gy/10 fractions, with mean hippocampal dose limited to 
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
ConclusionIn this experience neither prior PCI nor WBRT improved survival or local tumor control in SCLC patients who underwent SRS for new or recurrent brain disease.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Treatment of brain metastases from LCNEC of the lung with SRS was associated with improved survival. For the appropriate patients, upfront treatment of limited brain metastases with SRS may be appropriate. PMID: 30732516 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
This study aims to determine whether an additional...
Source: Radiation Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
Conventional whole brain radiotherapy (WBRT) has been established as the treatment standard in patients with cerebral metastases from small-cell lung cancer (SCLC), however, it has only modest efficacy and lim...
Source: Trials - Category: General Medicine Authors: Tags: Study protocol Source Type: research
Abstract BACKGROUND AND PURPOSE: We sought factors associated with the development of brain metastases after treatment of small cell lung cancer (SCLC) in patients without brain involvement at diagnosis. METHODS: We analyzed 293 patients with SCLC without brain metastases who received chemotherapy, thoracic radiation therapy (TRT), or both in 2001-2015. Pretreatment hematologic markers (platelet count, neutrophil count, lymphocyte count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lactate dehydrogenase) and other clinical characteristics were evaluated for correlation with brain metastas...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
1157Objectives: 1. Comparison between PET/CT and PET/MRI in detecting distant metastases of lung cancer 2. Review of the potential advantages of PET/MRI compared with PET/CT in assessment of patients with lung cancer 3. Highlight the limitations of PET/MRI in lung cancer assessment Abstract: Lung cancer is one of the most common cancers in the world, causing high morbidity and mortality, and is under active study through use of positron emission tomography/magnetic resonance imaging (PET/MRI). Lung cancers are divided into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) subtypes. The treatment and prog...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Educational Exhibits Source Type: research
Brain metastases (BM) are a common problem for patients with small-cell lung cancer (SCLC) [1]. Despite transitions to radiosurgery (SRS) alone for limited brain metastases (BM) in other histologies [2], whole brain radiation therapy (WBRT) remains the standard in SCLC regardless of the number of BM [3]. The continued acceptance of WBRT for limited and even solitary BM in SCLC may be driven by underlying concerns regarding the potential for diffuse CNS progression, as well as the historical role of prophylactic cranial irradiation (PCI) in the absence of identifiable BM.
Source: Lung Cancer - Category: Cancer & Oncology Authors: Tags: Short communication Source Type: research
CONCLUSIONS: Univariate analysis revealed that surgery followed by WBRT can improve OS in patients with SBM in SCLC. Furthermore, synchronous disease and response to initial chemotherapy appeared to be major prognostic factors. Multivariate analysis revealed metachronous disease as a significantly negative prognostic factor on OS. The value of WBRT, stereotactic radiosurgery (SRS), or surgery alone or in combination for patients with a limited number of BM in SCLC should be evaluated in further prospective clinical trials. PMID: 29085978 [PubMed - as supplied by publisher]
Source: Methods of Information in Medicine - Category: Information Technology Authors: Tags: Strahlenther Onkol Source Type: research
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