Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis

ConclusionsOur data indicates that dietary glutamine supplementation may act as a promising adjuvant for the treatment of visceral leishmaniasis.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research

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Leishmania is a parasitic protozoon responsible for the neglected tropical disease Leishmaniasis. Approximately, 350 million people are susceptible and close to 70,000 death cases globally are reported annually. The lack of effective leishmanicides, the emergence of drug resistance and toxicity concerns necessitate the pursuit for effective antileishmanial drugs. Natural compounds serve as reservoirs for discovering new drugs due to their chemical diversity. Hardwickiic acid (HA) isolated from the stembark of Croton sylvaticus was evaluated for its leishmanicidal potential against Leishmania donovani and L. major promastig...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Yu Y, Zhao P, Cao L, Gong P, Yuan S, Yao X, Guo Y, Dong H, Jiang W Abstract Leishmaniasis is a prevalent cause of death and animal morbidity in underdeveloped countries of endemic area. However, there is few vaccine and effective drugs. Antimicrobial peptides are involved in the innate immune response in many organisms and are being developed as novel drugs against parasitic infections. In the present study, we synthesized a 5-amino acid peptide REDLK, which mutated the C-terminus of Pseudomonas exotoxin, to identify its effect on the Leishmania tarentolae. Promastigotes were incubated with different conce...
Source: Korean Journal of Parasitology - Category: Parasitology Tags: Korean J Parasitol Source Type: research
This study aims to evaluate the efficacy of Apigenin against L.tropica amastigotes in vitro using Leishmania-Macrophage Interaction Assay. Our study demonstrated the possibility of efficacy of Apigenin against L.tropica amastigotes since Apigenin reduced the infection index at IC50 60.44 µM and this requires subsequent studies in humans and using Apigenin as a candidate for the chemotherapeutic treatment against Leishmaniasis.
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research
Background: Visceral leishmaniasis/HIV-co-infected patients (VL/HIV) accounts for around 8% of VL reported cases in Brazil. Relapses of Leishmania infection after anti-leishmanial treatment constitute a great challenge in the clinical practice because of the disease severity and drug resistance. We have shown that non-relapsing-VL/HIV (NR-) evolved with increase of CD4+ T-cell counts and reduction of activated CD4+ and CD8+ T cells after anti-leishmanial treatment. This immune profile was not observed in relapsing-VL/HIV patients (R-), indicating a more severe immunological compromising degree. Elevated activation status m...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study, High-Content Imaging System was used to demonstrate in vitro that sand fly saliva also promotes infection by these parasites. THP-1 cells were cultured in 96-well microplates and challenged with three strains of Leishmania braziliensis plus four dilutions of Nyssomyia neivai salivary gland extract. High-Content Imaging System equipment (Operetta CLS, Perkin Elmer) was configured to automatically count both cells and parasites inside the microplates and subsequently calculate the Infection Index (II). Results demonstrate that the extract concentration of 1 gland showed greater infection than other dilutions. ...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
Abstract People suffering from malnutrition show compromised levels of ω-6 fatty acid and malnutrition is frequently observed among visceral leishmaniasis (VL) patients as disease inflicts primarily the socioeconomic destitute communities. Dietary linoleic acid (LA, 18:2; ω-6 fatty acid) is the principal source of essential fatty acid and its derivatives i.e. eicosanoids possess immune-modulatory activities. However, its role in VL is not yet established. LA was measured in VL human subjects (serum) as well as in Leishmania donovani infected hamsters (serum and visceral organs). Organ-specific mRNA exp...
Source: Biochimie - Category: Biochemistry Authors: Tags: Biochimie Source Type: research
Conclusion: Overall, quinine sulphate microparticles had better pharmacokinetic profile and showed higher efficacy against Leishmania donovani parasites in vivo. Thus, quinine sulphate microparticles have the potential, especially, in treating visceral leishmaniasis. PMID: 32411255 [PubMed]
Source: Journal of Tropical Medicine - Category: Tropical Medicine Tags: J Trop Med Source Type: research
Abstract Leishmaniasis is one of the most important parasitic diseases, which is caused by Leishmania species. Nowadays; although pentavalent antimonials are used as the basic treatment option for Cutaneous Leishmaniasis, high cost, toxicity and resistance of the parasites to the medication over time are some important limitations causing several problems in the treatment. In recent years, the progress in the field of green nanotechnology provides the development of green nanoparticle-based treatment methods for Cutaneous Leishmaniasis. The importance of green nanoparticles has gradually increased due to their spe...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
[Complex cutaneous Leishmaniasis from the "Old World" : Therapeutic challenges in two complicated disease courses]. Hautarzt. 2020 May 11;: Authors: Gebhardt M, Völker K, Vanegas Ramirez A, Edler C, Fischer M Abstract Here we describe two complicated cases of complex Old World cutaneous Leishmaniasis due to L. infantum and L. aethiopica. Both of our patients infected with the Leishmania parasite presented with a completely different clinical picture, course of disease, and treatment response. Clinical healing was achieved after multiple courses of treatment with a var...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
Leishmania donovani-induced and sand fly-transmitted leishmaniasis is a growing health problem in Sri Lanka. Limited knowledge on biological and behavioral characteristics of probable vector Phlebotomus argentipe...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
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