The KdpD/KdpE two-component system contributes to the motility and virulence of avian pathogenic Escherichia coli

Publication date: Available online 25 March 2020Source: Research in Veterinary ScienceAuthor(s): Mei Xue, Muhammad Akmal Raheem, Yi Gu, Huiqi Lu, Xiangjun Song, Jian Tu, Ting Xue, Kezong Qi
Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research

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The well-known fact that avian pathogenic Escherichia coli (APEC) is harder to prevent due to its numerous serogroups has promoted the development of biological immunostimulatory materials as new vaccine candidat...
Source: Microbial Cell Factories - Category: Microbiology Authors: Tags: Research Source Type: research
Campylobacter jejuni monitors intestinal metabolites produced by the host and microbiota to initiate intestinal colonization of avian and animal hosts for commensalism and infection of humans for diarrheal disease. We previously discovered that C. jejuni has the capacity to spatially discern different intestinal regions by sensing lactate and the short-chain...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
Infection in the oviduct (salpingitis) is the most common bacterial infection in egg laying hens and is mainly caused by Escherichia coli. The disease is responsible for decreased animal welfare, considerable eco...
Source: BMC Veterinary Research - Category: Veterinary Research Authors: Tags: Research article Source Type: research
d Ahmed Ali Astroviruses belong to Astroviridae family which includes two main genera: Mamastroviruses that infect mammals, and Avastroviruses that infect avian hosts. Bats and wild birds are considered among the natural reservoirs for astroviruses. Infections in humans are associated with severe gastroenteritis, especially among children. We conducted surveillance for astroviruses in bats, wild birds, and humans in Egypt. Our results indicated relatively high prevalence of astroviruses in those hosts. Phylogenetic analysis revealed diversity of these viruses within hosts. Detected human viruses showed similarity with ...
Source: Viruses - Category: Virology Authors: Tags: Communication Source Type: research
Authors: Campana R, Baffone W Abstract Campylobacter acts using complex strategies to establish and promote intestinal infections. After ingestion via contaminated foods, this bacterium invades and can survive within the intestinal cells, also inducing epithelial translocation of non-invasive intestinal bacteria. In this investigation, the ability of human and avian C. jejuni and C. coli isolates to survive within two different intestinal epithelial cells lines, Caco-2 and INT 407, as well as the intestinal translocation phenomenon, was assessed. Our data demonstrated that both C. jejuni and C. coli strains survive...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Once a dangerous new pathogen is out, as we are seeing, it can be difficult if not impossible to prevent it going global. One as contagious as SARS-CoV-2 has the potential to infect the whole of humanity. Eighty per cent of cases may be benign, but with such a large pool of susceptible hosts, the numbers who experience severe illness and die can still be shockingly high. So the only sensible answer to the question, how do we stop this from happening again, is: by doing all we can to prevent such pathogens infecting humans in the first place. And that means taking a long, hard look at our relationship with the natural world...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
Microbial survival in blood is an essential step toward the development of disseminated diseases and blood stream infections. For poultry, however, little is known about the interactions of host cells and pathogens in blood. We established an ex vivo chicken whole-blood infection assay as a tool to analyze interactions between host cells and three model pathogens, Escherichia coli, Staphylococcus aureus, and Candida albicans. Following a systems biology approach, we complemented the experimental measurements with functional and quantitative immune characteristics by virtual infection modeling. All three pathogens were kill...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 24 March 2020Source: Veterinary MicrobiologyAuthor(s): E. Cuevas-Ferrando, P. Guirado, E. Miró, Y. Iglesias-Torrens, F. Navarro, T.S. Alioto, J. Gómez-Garrido, C. Madrid, C. Balsalobre
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
In conclusion, CG analysis defined five new subclades. The ST131 porcine isolates belonged to new subclades B6 and B7. Moreover, porcine and clinical human isolates were strongly related. The 11 porcine ST131 isolates harbored a wide variety of plasmids, virulence, and resistance genes. Furthermore, epidemic plasmids IncX4 and IncHI2 are responsible for the acquisition of mcr-1.1 gene. We hypothesize that the APEC-IncF plasmid acquired the mcr-1.1 gene via cointegrating an IncHI2 plasmid, which is worrying due to combination of virulence and resistance attributes in a single mobile genetic element.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
We sequenced the whole genomes of three mcr-1-positive multidrug-resistant E. coli strains, which were previously isolated from the environment of egret habitat (polluted river) and egret feces. The results exhibit high correlation between antibiotic-resistant phenotype and genotype among the three strains. Most of the mobilized antibiotic resistance genes (ARGs) are distributed on plasmids in the forms of transposons or integrons. Multidrug-resistant (MDR) regions of high homology are detected on plasmids of different E. coli isolates. Therefore, horizontal transfer of resistance genes has facilitated the transmission of ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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