FEV1 and MRI ventilation defect reversibility in asthma and COPD

The underlying pathophysiological determinants of asthma and COPD are related in complex ways. Importantly however, post-bronchodilator forced expiratory volume in 1 s (FEV1) reversibility may occur in approximately 50% of COPD patients [1], whilst epidemiological [2] and magnetic resonance imaging (MRI) studies [3] suggest that, in asthma patients, FEV1 reversibility may diminish over time. As compared to patients with asthma or COPD alone, patients with co-existing asthma and COPD report worse clinical outcomes [4] and increased healthcare costs [5] and burden [4, 5].

Source: European Respiratory Journal - March 25, 2020 Category: Respiratory Medicine Authors: Serajeddini, H., Eddy, R. L., Licskai, C., McCormack, D. G., Parraga, G. Tags: Original Articles: Research letters Source Type: research