The Gut Microbiome as a Contributing Factor in Alzheimer ' s Disease

The gut microbiome changes with age in ways that provoke chronic inflammation. Beneficial microbial populations decline in number while harmful populations expand. This is likely the result of numerous contributing factors, including dietary changes characteristic of age and the decline of the immune system, but at this point it is a challenge to pin down which of these processes are more versus less important to the overall outcome. It is well known that chronic inflammation drives a faster progression of many of the common age-related diseases, including neurodegenerative conditions. Thus it is expected to find links between the gut microbiome and conditions such as Alzheimer's disease, as is discussed here. Factors that may be involved in the development of Alzheimer's disease are thought to include lifestyle habits. Lifestyle dysregulation may not only lead to Alzheimer's disease, but also to various other health problems such as dysregulation of the gut microbiota. The composition of symbiotic microorganisms has changed dramatically throughout human history with the development of agriculture, industrialization, and globalization. It is postulated that each of these lifestyle changes resulted in a gradual disappearance of microbial diversity and an increase in their virulence, thus causing the formation of a risk path for Alzheimer's disease pathogenesis. Changes in the microbial composition throughout history suggest an escalation of the risk of Alzheimer's dis...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs