Ocular Graft-Versus-Host Disease Topic Review

AbstractPurposeThis review offers an informed insight on the pathophysiology of ocular graft-versus-host disease in addition to up-to-date recommendations for monitoring and management.Recent FindingsOcular GVHD is estimated to affect tens of thousands of individuals in the USA. It is not known how many of these patients are aware of their condition or seek therapy for it. Diagnosis of ocular GVHD poses a difficult challenge due to the unspecific nature of the presentation. However, improvement in diagnostic criteria through available testing and updated guidelines can allow early identification promoting appropriate intervention.SummaryGVHD is a systemic disease that can involve any organ including the eye. Ocular GVHD is estimated to affect 40 –60% of patients undergoing allogeneic hematopoietic stem cell transplant. The disease can result in significant morbidity and mortality and continues to pose a diagnostic challenge despite continuous revision of the available criteria. Multiple therapeutic options are available and have shown pro mise. Despite its systemic underlying etiology, organ-specific ocular GVHD is best treated through organ-specific topical management which allows reduction of symptoms and complications.
Source: Current Ophthalmology Reports - Category: Opthalmology Source Type: research