LncRNA CASC2 inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation and migration by regulating the miR-222/ING5 axis.

Conclusion: CASC2 attenuated hypoxia-induced PASMC proliferation and migration by regulating the miR-222/ING5 axis to prevent vascular remodeling and the development of PAH, providing a novel insight and therapeutic strategy for hypoxia-induced PAH. PMID: 32206065 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/32206065?dopt=Abstract

Source: Cellular and Molecular Biology Letters - March 26, 2020 Category: Biochemistry Authors: Han Y, Liu Y, Yang C, Gao C, Guo X, Cheng J Tags: Cell Mol Biol Lett Source Type: research