Opioid Toxidrome Following Grapefruit Juice Consumption in the Setting of Methadone Maintenance

Conclusions: Grapefruit juice inhibits the metabolism of methadone, raising its serum levels. To our knowledge, this is the first reported case in which the interaction between grapefruit juice and methadone was significant enough to cause an opioid toxidrome. It is, therefore, recommended that opioid treatment programs (OTPs) advise patients about this interaction before administering methadone.
Source: Journal of Addiction Medicine - Category: Addiction Tags: Case Reports Source Type: research