Molecular Interrogation to Crack the Case of O-GlcNAc.

Molecular Interrogation to Crack the Case of O-GlcNAc. Chemistry. 2020 Mar 23;: Authors: Estevez A, Zhu D, Blankenship C, Jiang J Abstract The O-linked β-N-acetylglucosamine (O-GlcNAc) modification, termed O-GlcNAcylation, is an essential and dynamic post-translational modification in cells. O-GlcNAc transferase (OGT) installs this modification on serine and threonine residues while O-GlcNAcase (OGA) hydrolyzes it. O-GlcNAc modifications are found on thousands of intracellular proteins involved in diverse biological processes. Dysregulation of O-GlcNAcylation and O-GlcNAc cycling enzymes has been detected in many diseases including cancer, diabetes, cardiovascular and neurodegenerative diseases. In this minireview, we will discuss recent advances in the development of molecular tools to investigate OGT and OGA functions and substrate recognition. We will also cover new chemical approaches to study O-GlcNAc dynamics and its potential roles in the immune system. We hope this minireview will encourage more research in these areas to advance understanding of O-GlcNAc in biology and diseases. PMID: 32207184 [PubMed - as supplied by publisher]
Source: Chemistry - Category: Chemistry Authors: Tags: Chemistry Source Type: research